Department of Ilmul Advia (Pharmacology), Government Unani Medical College, Rajiv Gandhi University of Health Sciences, Bengaluru-560079, Karnataka, India; Department of Ilmul Advia (Pharmacology), National Institute of Unani Medicine, Rajiv Gandhi University of Health Sciences, Bengaluru-560091, Karnataka, India.
Department of Ilmul Advia (Pharmacology), National Institute of Unani Medicine, Rajiv Gandhi University of Health Sciences, Bengaluru-560091, Karnataka, India.
J Integr Med. 2020 Mar;18(2):114-124. doi: 10.1016/j.joim.2020.01.003. Epub 2020 Jan 13.
In an era of globalization and increased global demand for herbal medicines, it is essential to ensure the quality and consistency of drugs. Changes in the quality of an herbal product over time should be detectable. The assessments of chemical quality and therapeutic efficacy of herbal drugs are necessary to establish their shelf-lives. Thus, stability testing is needed to establish standards for herbal products. Unani medicine has its own conceptual framework for studying health and disease. The mode of treatment includes Ilaj bit Tadbeer (regimental therapy), Ilaj bil Ghiza (dietotherapy), Ilaj bil Dawa (pharmacotherapy) and Ilaj bil Yad/Jarahat (surgery) as a final option. Ilaj bil Dawa is the most used mode of treatment. The drugs include either crude drugs prepared from plant, animal and mineral sources, called Mufrad (single) drugs or various formulations prepared from these crude drugs, called Murakkab (compound) drugs. To date, stability studies have been carried out on compound drugs, whereas only a few single drugs had had their stability tested. These studies are needed to understand how the quality of an herbal drug varies over the time when it is prepared and consumed. This may also help to standardize procedures for manufacturing compound formulations ab initio. The present study reviews the concept of Aamar-e-Advia (shelf-lives) described in the literature of the Unani system of medicine. Further, various factors that are considered important to assess the shelf-life of Unani drugs are discussed in the context of contemporary protocols for shelf-life assessment.
在全球化和全球对草药需求增加的时代，确保药物的质量和一致性至关重要。应能检测到草药产品质量随时间的变化。有必要评估草药药物的化学质量和治疗功效，以确定其保质期。因此，需要稳定性测试来为草药产品建立标准。顺势疗法有其自己的研究健康和疾病的概念框架。治疗模式包括 Ilaj bit Tadbeer（常规疗法）、Ilaj bil Ghiza（食疗）、Ilaj bil Dawa（药物疗法）和 Ilaj bil Yad/Jarahat（手术）作为最后的选择。Ilaj bil Dawa 是最常用的治疗模式。药物包括来自植物、动物和矿物来源的原料药，称为 Mufrad（单一）药物，或由这些原料药制成的各种制剂，称为 Murakkab（复方）药物。迄今为止，已经对复方药物进行了稳定性研究，而只有少数单一药物进行了稳定性测试。这些研究有助于了解草药药物在制备和使用过程中质量随时间的变化。这也有助于从一开始就为复方制剂的制造标准化程序。本研究综述了顺势疗法医学文献中描述的 Aamar-e-Advia（保质期）的概念。此外，还根据当代保质期评估协议讨论了评估顺势疗法药物保质期的重要因素。
