Shimokawa Yu, Yamada Yuki, Kawanami Kanako, Yamaki Tetsu, Sonoda Yukihiko
Department of Neurosurgery, Yamagata University Faculty of Medicine.
No Shinkei Geka. 2020 Jan;48(1):63-69. doi: 10.11477/mf.1436204135.
Metastatic meningiomas are extremely rare, and generally have poor prognosis. We report a case of atypical meningioma with good clinical course despite metastasis 9 years after the initial surgery. CASE:A 58-year-old woman visited a nearby hospital with complaints of hemiplegia and aphasia. MRI showed a large left frontal meningioma;she was referred to our department where she underwent a tumor resection(Simpson Grade I). Histopathological finding revealed fibrous meningioma in the prominent part of the tumor. Additionally, a small lesion with high Ki-67 labeling index was identified;therefore, the final diagnosis was atypical meningioma. Nine years postoperatively, a hepatic mass found incidentally and was resected by digestive surgery;a histological diagnosis of metastatic atypical meningioma was established. Thirteen years after the first operation, routine MRI showed enlargement of the local recurrent lesions in the tumor resection cavity. She underwent a reoperation(Simpson Grade I)at our department, and subsequently, discharged without any neurological deficits. Findings were not suggestive of atypical meningioma. Studies report three good prognostic factors in patients with metastatic meningioma-histologically benign primary tumor, long interval between initial diagnosis and metastasis, and asymptomatic metastatic lesion.
转移性脑膜瘤极为罕见,且通常预后较差。我们报告一例非典型脑膜瘤病例,尽管在初次手术后9年发生了转移,但临床病程良好。病例:一名58岁女性因偏瘫和失语前往附近医院就诊。磁共振成像(MRI)显示左额叶有一个大的脑膜瘤;她被转诊至我院,在我院接受了肿瘤切除术(辛普森一级)。组织病理学检查发现肿瘤突出部分为纤维性脑膜瘤。此外,还发现一个Ki-67标记指数较高的小病灶;因此,最终诊断为非典型脑膜瘤。术后9年,偶然发现肝脏有一个肿块,经消化外科手术切除;组织学诊断为转移性非典型脑膜瘤。首次手术后13年,常规MRI显示肿瘤切除腔内局部复发病灶增大。她在我院接受了再次手术(辛普森一级),随后出院,无任何神经功能缺损。检查结果不提示为非典型脑膜瘤。研究报告了转移性脑膜瘤患者的三个良好预后因素——组织学上为良性原发性肿瘤、初次诊断与转移之间的间隔时间长以及无症状转移性病灶。