Di Renzo Dacia, Pizzuti Giada, Lauriti Giuseppe, Cascini Valentina, Lelli Chiesa Pierluigi
Department of Medicine and Aging Sciences, "G. d'Annunzio" University of Chieti-Pescara, Chieti, Italy.
Department of Pediatric Surgery, "Spirito Santo" Hospital of Pescara, Pescara, Italy.
Indian J Urol. 2020 Jan-Mar;36(1):26-31. doi: 10.4103/iju.IJU_216_19.
Few case series report the use of holmium: yttrium-aluminum-garnet (Ho:YAG) laser to decompress ureterocele (UC) in pediatric population, and only two studies compared its outcomes with electrosurgery. This study aims to compare outcomes of Ho:YAG laser transurethral endoscopic puncture (TUP) versus electrosurgery TUP of UC in the 1 month of life, analyzing incidence of secondary surgery, redo TUP, and iatrogenic vesicoureteral reflux (VUR).
A retrospective study of patients treated by TUP of UC from 2008 to 2017 was performed. Those undergoing Ho:YAG laser TUP were included in Group A, those undergoing electrocautery TUP were included in Group B. Data were compared using Fisher's exact test.
Group A included seven patients (mean follow-up 4 years). Two required a redo TUP. Two had preoperative VUR, which resolved after TUP. Two developed VUR after TUP, which resolved spontaneously. No secondary surgery was required. Group B included nine patients (mean follow-up: 9.5 years). One required a redo TUP. Preoperative VUR was detected in 4/9 and persisted after TUP in 2. Three developed post-TUP VUR, which persisted. Five required further surgery because of persistent and symptomatic VUR. Secondary surgery was significantly lower after Ho:YAG laser compared to electrocautery TUP ( < 0.05). The incidences of both redo TUP and postoperative VUR were not significantly different between the two groups ( = ns).
Ho:YAG laser TUP seems to be safe and effective in the decompression of obstructive UCs and maybe advantageous over electrocautery puncture. However, further studies with larger cohort are needed to corroborate our preliminary results.
很少有病例系列报道在儿科人群中使用钬:钇铝石榴石(Ho:YAG)激光对输尿管囊肿(UC)进行减压,并且只有两项研究将其结果与电外科手术进行了比较。本研究旨在比较出生后1个月内Ho:YAG激光经尿道内镜穿刺(TUP)与UC电外科TUP的结果,分析二次手术、再次TUP和医源性膀胱输尿管反流(VUR)的发生率。
对2008年至2017年接受UC TUP治疗的患者进行回顾性研究。接受Ho:YAG激光TUP的患者纳入A组,接受电灼TUP的患者纳入B组。使用Fisher精确检验比较数据。
A组包括7例患者(平均随访4年)。2例需要再次TUP。2例术前有VUR,TUP后消失。2例TUP后出现VUR,随后自行消失。无需二次手术。B组包括9例患者(平均随访:9.5年)。1例需要再次TUP。4/9例术前检测到VUR,2例TUP后持续存在。3例TUP后出现VUR,持续存在。5例因持续性和有症状的VUR需要进一步手术。与电灼TUP相比,Ho:YAG激光治疗后的二次手术明显更少(<0.05)。两组再次TUP和术后VUR的发生率无显著差异(=无统计学意义)。
Ho:YAG激光TUP在梗阻性UC减压中似乎是安全有效的,可能比电灼穿刺更具优势。然而,需要更大队列的进一步研究来证实我们的初步结果。