Faculty of Medicine, Department of Pathology, Mansoura University, Mansoura, Egypt.
Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Fetal Pediatr Pathol. 2021 Oct;40(5):395-406. doi: 10.1080/15513815.2020.1716902. Epub 2020 Jan 25.
Few studies have correlated pediatric endoscopic and histologic impressions of duodenal biopsies. This is a retrospective study on children undergoing upper gastrointestinal endoscopy over a period of 11 years. We investigated concordance between the gross endoscopic and histopathologic characteristics of pediatric duodenal biopsies. Of 1793 children enrolled in the study, duodenal pathology was observed in 72.3%. The gross endoscopic findings showed a low sensitivity of 38.9%, specificity of 99.2%, PPV of 99.2%, and NPV of 38.3%. Concordance between the gross endoscopic and histopathologic analysis was 55.6%. This study showed a higher rate of pediatric duodenal pathologies than gross assessment. This emphasizes the value for acquiring routine duodenal biopsies from grossly normal mucosa.
很少有研究将儿科内镜和组织学印象与十二指肠活检相关联。这是一项对 11 年间进行上消化道内镜检查的儿童进行的回顾性研究。我们研究了儿科十二指肠活检的大体内镜和组织病理学特征之间的一致性。在纳入研究的 1793 名儿童中，72.3%观察到十二指肠病变。大体内镜检查结果显示出较低的敏感性（38.9%）、特异性（99.2%）、PPV（99.2%）和 NPV（38.3%）。大体内镜检查和组织病理学分析之间的一致性为 55.6%。这项研究表明，儿科十二指肠病变的发生率高于大体评估。这强调了从大体正常黏膜中获取常规十二指肠活检的价值。
