Department of Surgical Pathology, the Affiliated Women's Hospital, School of Medicine, Zhejiang University, Zhejiang Province, China.
Int J Gynecol Pathol. 2020 Nov;39(6):546-551. doi: 10.1097/PGP.0000000000000639.
Mesonephric adenocarcinoma (MA) is a rare tumor of the female genital tract that develops in the uterine cervix. Recently, a few cases of MA arising from the uterine body have been reported, whereas the differences between these 2 entities remain unknown. Two uterine MAs and 1 cervical MA were included in this study. In uterine MA, there was an admixture of various growth patterns with tubular, glandular, slit-like, papillary, and solid architectures. Both tumors extensively involved the endometrium, while no mesonephric remnants were noted. Immunostaining was diffusely positive for TTF-1, while there was only focal staining for GATA3. KRAS somatic mutation was present in both uterine cases. In cervical MA, the tumor also had different growth patterns but no endocervical mucosa involvement. A residual mesonephric duct was present. GATA3 showed diffuse staining, but TTF-1 was totally negative. Therefore, uterine MA was not entirely consistent with its cervical counterpart in both morphologic characteristics and immunostaining.
中肾腺癌（MA）是一种罕见的女性生殖道肿瘤，发生在子宫颈。最近，有少数来源于子宫体的 MA 病例报道，然而这两种实体之间的差异尚不清楚。本研究纳入了 2 例子宫 MA 和 1 例宫颈 MA。在子宫 MA 中，存在多种生长模式的混合，包括管状、腺状、裂隙状、乳头状和实性结构。两个肿瘤广泛累及子宫内膜，而没有发现中肾残留。免疫组化染色TTF-1 弥漫阳性，而 GATA3 仅呈局灶性染色。两个子宫 MA 均存在 KRAS 体细胞突变。在宫颈 MA 中，肿瘤也具有不同的生长模式，但没有累及宫颈内膜。存在残留的中肾管。GATA3 呈弥漫性染色，而 TTF-1 完全阴性。因此，子宫 MA 在形态特征和免疫组化染色方面与宫颈 MA 并不完全一致。
