From the Department of Plastic and Cosmetic Surgery, Nanfang Hospital, Southern Medical University.
Plast Reconstr Surg. 2020 Feb;145(2):345-353. doi: 10.1097/PRS.0000000000006456.
Horizontal neck wrinkles develop as a result of the aging process. Stromal vascular fraction (SVF) gel, which is rich in extracellular matrix and functional cells, can be produced by a series of simple mechanical processes, including intersyringe shifting and centrifugation. This study aimed to assess stromal vascular fraction gel in the treatment of horizontal neck wrinkles.
This single-center study included female patients with horizontal neck wrinkles (Fitzpatrick types II to IV) treated with either SVF gel or botulinum toxin type A (BTX A) injection. SVF gel was first diffusely distributed subcutaneously along the neck line and then injected in a diluted way intracutaneously at points 0.5 cm apart along the horizontal lines. BTX A was injected at points 1.5 cm apart (2 U in each injection site). Satisfaction and improvement scores were compared between the two groups, and the collagen content of the neck wrinkle was compared by histologic evaluation before and after treatment.
Twenty-eight patients received SVF gel and 22 received BTX A. In patients with type II neck wrinkles, BTX A and SVF gel treatment resulted in similar improvement scores and patient satisfaction in the first 3 months. In patients with type III and IV neck wrinkles, SVF gel resulted in significantly higher improvement scores and better patient satisfaction. A longer duration of adverse events was seen in the SVF gel treatment group. Histologic assessment suggested that SVF gel increased the collagen density of neck wrinkles.
SVF gel is an effective treatment for horizontal neck wrinkles, particularly in patients with type III and IV wrinkles.
CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, II.
水平颈部皱纹是衰老过程的结果。基质血管成分 (SVF) 凝胶富含细胞外基质和功能细胞，可通过一系列简单的机械过程产生，包括注射器间转移和离心。本研究旨在评估基质血管成分凝胶在治疗水平颈部皱纹中的作用。
本单中心研究纳入了接受 SVF 凝胶或肉毒毒素 A 注射（BTX A）治疗的水平颈部皱纹（Fitzpatrick 类型 II 至 IV）的女性患者。SVF 凝胶首先沿颈线皮下广泛分布，然后以稀释的方式在水平线上每隔 0.5cm 的点进行皮内注射。BTX A 以 1.5cm 的间隔点注（每个注射部位 2U）。比较两组之间的满意度和改善评分，并通过治疗前后的组织学评估比较颈部皱纹的胶原含量。
28 名患者接受 SVF 凝胶治疗，22 名患者接受 BTX A 治疗。在 II 型颈纹患者中，BTX A 和 SVF 凝胶治疗在治疗后的前 3 个月内，改善评分和患者满意度相似。在 III 型和 IV 型颈纹患者中，SVF 凝胶治疗的改善评分显著更高，患者满意度更好。SVF 凝胶治疗组的不良反应持续时间更长。组织学评估表明，SVF 凝胶增加了颈部皱纹的胶原密度。
SVF 凝胶是治疗水平颈部皱纹的有效方法，特别是对于 III 型和 IV 型皱纹患者。
临床问题/证据水平：治疗，II 级。
