Lande R Gregory
J Am Osteopath Assoc. 2020 Feb 1;120(2):100-106. doi: 10.7556/jaoa.2020.019.
Depression is one of the most commonly diagnosed psychiatric disorders, but antidepressant pharmacotherapy often fails to achieve remission, leading health care professionals and researchers to consider various augmentation strategies to improve clinical outcomes.
To assess the safety, tolerability, and efficacy of nutraceutical augmentation for depression.
Nutraceutical-focused systematic reviews and clinical practice guidelines identified the more commonly studied augmentation strategies for depression.
S-adenosylmethionine, l-methylfolate, omega-3 fatty acids, and hydroxyvitamin D have sufficient scientific evidence to support their clinical consideration in the stepped care approach to the management of depression.
Clinical remission is the goal in the management of depression, and nutraceuticals may be part of an overall treatment approach to achieve that outcome.
抑郁症是最常被诊断出的精神疾病之一，但抗抑郁药物治疗往往无法实现症状缓解，这促使医疗保健专业人员和研究人员考虑各种增效策略以改善临床疗效。
评估营养补充剂增效治疗抑郁症的安全性、耐受性和疗效。
以营养补充剂为重点的系统评价和临床实践指南确定了更常被研究的抑郁症增效策略。
S-腺苷甲硫氨酸、L-甲基叶酸、ω-3脂肪酸和羟基维生素D有足够的科学证据支持在抑郁症管理的阶梯式治疗方法中对其进行临床考量。
临床缓解是抑郁症管理的目标，营养补充剂可能是实现这一结果的整体治疗方法的一部分。
