Cotofana Sebastian, Hexsel Doris, Avelar Luiz E.T., Munia Christine G., Muniz Mariana, Casabona Gabriela, Schenck Thilo L., Green Jeremy B., Lachman Nirusha, Frank Konstantin
J Drugs Dermatol. 2020 Jan 1;19(1):36-44. doi: 10.36849/JDD.2020.4619.
Injections of biostimulator agents are increasing in popularity as an alternative to surgical or energy-based skin tightening procedures. The present study was designed to develop a formula that helps to guide health care providers injecting biostimulators into the correct plane to enhance effectiveness and longevity by targeting precisely the superficial fascial system. METHODS: 150 Caucasian individuals (75 males and 75 females) were investigated with a balanced distribution of age (n=30 per decade: 20–29, 30–39, 40–49, 50–59, and 60–69 years) and body mass index (n=50 per group: BMI≤24.9kg/m2, BMI between 25.0 and 29.9kg/m2 BMI≥30kg/m2). The distance between skin surface and the superficial fascia was measured via ultrasound in the buccal region, premasseteric region, the lateral neck, posterior arm, abdomen, buttocks, anterior thigh, medial thigh, and posterior thigh. RESULTS: Mean thickness of the superficial fatty layer is variable between the different locations investigated with smallest values for the lateral neck of 3.71mm ± 0.55 [range, 2.00–5.00mm] and greatest values for the gluteal region with 20.52mm±10.07 [range, 6.10–38.40mm]. A formula was developed to estimate the thickness of the superficial fatty layer based on the targeted region, age, gender, and body mass index of the patient: Thickness of superficial fatty layer (mm): Region constant + (XX* BMI) - (YY*Age). CONCLUSIONS: Injections of biostimulators deeper than the calculated values might result in reduced efficacy as the superficial fascial system is not targeted and the effected collagen neogenesis does not affect the skin surface. J Drugs Dermatol. 2020;19(1):36-44. doi:10.36849/JDD.2020.4619
作为手术或基于能量的皮肤紧致手术的替代方法,生物刺激剂注射越来越受欢迎。本研究旨在开发一种配方,通过精确靶向浅筋膜系统,帮助指导医疗保健人员将生物刺激剂注射到正确层面,以提高疗效和延长效果持续时间。方法:对150名白种人(75名男性和75名女性)进行了调查,年龄(每十年n = 30名:20 - 29岁、30 - 39岁、40 - 49岁、50 - 59岁和60 - 69岁)和体重指数(每组n = 50名:BMI≤24.9kg/m²、BMI在25.0至29.9kg/m²之间、BMI≥30kg/m²)分布均衡。通过超声测量颊部、咬肌前区、颈部外侧、上臂后侧、腹部、臀部、大腿前侧、大腿内侧和大腿后侧皮肤表面与浅筋膜之间的距离。结果:在所研究的不同部位,浅表脂肪层的平均厚度各不相同,颈部外侧最小,为3.71mm±0.55[范围,2.00 - 5.00mm],臀部区域最大,为20.52mm±10.07[范围,6.10 - 38.40mm]。根据患者的目标区域、年龄、性别和体重指数,开发了一个估计浅表脂肪层厚度的公式:浅表脂肪层厚度(mm):区域常数 +(XX * BMI)-(YY * 年龄)。结论:如果生物刺激剂的注射深度超过计算值,可能会导致疗效降低,因为浅筋膜系统未被靶向,且所产生的胶原新生不影响皮肤表面。《药物皮肤病学杂志》。2020年;19(1):36 - 44。doi:10.36849/JDD.2020.4619