Institute of Lung Biology and Disease, Helmholtz Zentrum München, Max-Lebsche-Platz 31, 81377 Munich, Germany.
Institute of Regenerative Biology and Medicine, Helmholtz Zentrum München, Max-Lebsche-Platz 31, 81377 Munich, Germany.
Int J Mol Sci. 2021 Aug 20;22(16):9006. doi: 10.3390/ijms22169006.
Mammals rapidly heal wounds through fibrous connective tissue build up and tissue contraction. Recent findings from mouse attribute wound healing to physical mobilization of a fibroelastic connective tissue layer that resides beneath the skin, termed subcutaneous fascia or superficial fascia, into sites of injury. Fascial mobilization assembles diverse cell types and matrix components needed for rapid wound repair. These observations suggest that the factors directly affecting fascial mobility are responsible for chronic skin wounds and excessive skin scarring. In this review, we discuss the link between the fascia's unique tissue anatomy, composition, biomechanical, and rheologic properties to its ability to mobilize its tissue assemblage. Fascia is thus at the forefront of tissue pathology and a better understanding of how it is mobilized may crystallize our view of wound healing alterations during aging, diabetes, and fibrous disease and create novel therapeutic strategies for wound repair.
哺乳动物通过纤维结缔组织的积累和组织收缩来快速愈合伤口。最近来自老鼠的研究结果表明，伤口愈合归因于位于皮肤下方的纤维弹性结缔组织层（称为皮下筋膜或浅筋膜）的物理迁移到损伤部位。筋膜迁移可组装多种细胞类型和基质成分，这些成分是快速伤口修复所必需的。这些观察结果表明，直接影响筋膜活动性的因素是导致慢性皮肤伤口和过度皮肤瘢痕的原因。在这篇综述中，我们讨论了筋膜独特的组织解剖、组成、生物力学和流变学特性与其组织组装迁移能力之间的联系。因此，筋膜处于组织病理学的前沿，更好地了解筋膜如何迁移可能会改变我们对衰老、糖尿病和纤维性疾病期间伤口愈合改变的看法，并为伤口修复创造新的治疗策略。
