Departamento de Neurofisiología, Instituto Nacional de Neurología y Neurocirugía, 14269 Ciudad de México, CDMX, Mexico.
CNS Neurol Disord Drug Targets. 2020;19(1):2-11. doi: 10.2174/1871527319666200120143133.
Epilepsy is a neurological disorder that involves abnormal and recurrent neuronal discharges, producing epileptic seizures. Recently, it has been proposed that the Wnt signaling pathway is essential for the central nervous system development and function because it modulates important processes such as hippocampal neurogenesis, synaptic clefting, and mitochondrial regulation. Wnt/β- catenin signaling regulates changes induced by epileptic seizures, including neuronal death. Several genetic studies associate Wnt/β-catenin signaling with neuronal excitability and epileptic activity. Mutations and chromosomal defects underlying syndromic or inherited epileptic seizures have been identified. However, genetic factors underlying the susceptibility of an individual to develop epileptic seizures have not been fully studied yet. In this review, we describe the genes involved in neuronal excitability in epileptogenic zones dependent on the Wnt/β-catenin pathway.
癫痫是一种涉及异常和反复神经元放电的神经系统疾病，会引发癫痫发作。最近有人提出，Wnt 信号通路对中枢神经系统的发育和功能至关重要，因为它调节了许多重要的过程，如海马神经发生、突触分裂和线粒体调节。Wnt/β-连环蛋白信号调节癫痫发作引起的变化，包括神经元死亡。一些遗传研究将 Wnt/β-连环蛋白信号与神经元兴奋性和癫痫活动联系起来。已经确定了与综合征或遗传性癫痫发作相关的 Wnt/β-连环蛋白信号的突变和染色体缺陷。然而，个体易患癫痫发作的遗传因素尚未得到充分研究。在这篇综述中，我们描述了与 Wnt/β-连环蛋白通路相关的致痫区神经元兴奋性的相关基因。
