Centro Hospitalar e Universitário São João, Porto, Portugal; Faculdade de Medicina da Universidade do Porto, Portugal.
Centro Hospitalar e Universitário São João, Porto, Portugal.
Surg Oncol. 2020 Mar;32:108-114. doi: 10.1016/j.suronc.2019.11.008. Epub 2019 Nov 25.
OSNA is a molecular assay for the detection of sentinel node metastasis. TTL emerged as a concept that seems to accurately predict the status of the NSN. Authors tried to confirm this motion. This is a retrospective and multicentric study that analyzed 2164 patients, 579 of whom had positive SN and completion AD. Logistic regression models were performed in order to identify a suitable cutoff to identify patients who benefit from AD. Univariate and multivariate regression analysis showed a relationship between TTL>30000 and the presence of NSN metastasis (OR 2.84, CI 1.99-4.08, p < 0.001). Logistic regression indicated that the cutoff of 30000 copies/μL better discriminates patients with NSN positivity and allows wide use of these criteria. This cutoff value may safely assist clinicians and patients to decide to proceed or not with an AD.
OSNA 是一种用于检测前哨淋巴结转移的分子检测方法。TTL 作为一种概念出现，似乎可以准确预测 NSN 的状态。作者试图证实这一观点。这是一项回顾性的多中心研究，共分析了 2164 例患者，其中 579 例 SN 阳性且完成了 AD。为了确定能够识别从 AD 中获益的患者的合适截止值，进行了逻辑回归模型分析。单变量和多变量回归分析显示，TTL>30000 与 NSN 转移的存在之间存在关联（OR 2.84，95%CI 1.99-4.08，p<0.001）。逻辑回归表明，30000 拷贝/μL 的截止值更能区分 NSN 阳性患者，并允许广泛使用这些标准。该截断值可以安全地帮助临床医生和患者决定是否进行 AD。
