Department of neuroradiology, hôpital Pierre Wertheimer, hospices civils de Lyon, 69500 Bron, France.
Department of neuroradiology, hôpital Pierre Wertheimer, hospices civils de Lyon, 69500 Bron, France; CREATIS CNRS UMR 5220, Inserm U1044, Lyon 1 university, 69100 Villeurbanne, France.
Rev Neurol (Paris). 2020 Mar;176(3):194-199. doi: 10.1016/j.neurol.2019.07.022. Epub 2020 Jan 25.
Intracranial plaque gadolinium enhancement revealed by high-resolution MRI imaging (HR MRI) is considered as a marker of plaque inflammation, a contributing factor of plaque unstability. The aim of the present study was to assess the distribution of gadolinium enhancement in intracranial atherosclerosis.
Single center analysis of ischemic stroke patients with intracranial atherosclerotic stenosis of M1 or M2 segments of middle cerebral artery, or terminal internal carotid artery (ICA) based on CT-angio or MR-angio. High-resolution MRI imaging (HRMRI) was performed within 6 first weeks following the index event, with 3DT2 BB (black-blood) and 3D T1 BB MR sequences pre and post-contrast administration.
We identified 8 patients with 14 plaques, 4 were deemed non-culprit and 10 culprit. All culprit plaques (10/10 plaques) and 3 out of 4 non-culprit plaques showed a gadolinium enhancement.
At the acute/subacute stage of stroke, a gadolinium enhancement may affect multiple asymptomatic intracranial plaques and may reflect a global inflammatory state.
高分辨率磁共振成像（HR MRI）显示的颅内斑块钆增强被认为是斑块炎症的标志物，是斑块不稳定的一个促成因素。本研究旨在评估颅内动脉粥样硬化中钆增强的分布。
基于 CT 血管造影或 MR 血管造影，对 M1 或 M2 段大脑中动脉或颈内动脉终末段（ICA）有颅内动脉粥样硬化性狭窄的缺血性脑卒中患者进行单中心分析。在指数事件发生后的 6 周内进行高分辨率 MRI 成像（HRMRI），使用 3DT2 BB（黑血）和 3D T1 BB MR 序列进行对比前和对比后检查。
我们共确定了 8 名患者的 14 个斑块，其中 4 个被认为是非罪犯斑块，10 个为罪犯斑块。所有罪犯斑块（10/10 个斑块）和 4 个非罪犯斑块中的 3 个均显示出钆增强。
在卒中的急性/亚急性期，钆增强可能会影响多个无症状的颅内斑块，并且可能反映了一种全身性炎症状态。
