CHU de Caen, Caen; Neuropsychologie et Imagerie de la Mémoire Humaine, UNICAEN, PSL Research University, Normandie Université, Inserm, EPHE, Caen, France.
Neuropsychologie et Imagerie de la Mémoire Humaine, UNICAEN, PSL Research University, Normandie Université, Inserm, EPHE, Caen, France; CRPCPO, EA 7273, Université de Picardie Jules-Verne, Amiens, France.
Rev Neurol (Paris). 2020 May;176(4):285-288. doi: 10.1016/j.neurol.2019.08.011. Epub 2020 Jan 25.
Transient global amnesia (TGA) can be triggered by a high level of blood cortisol. We assessed whether patients had a higher level of cortisol during the TGA than shortly after. We included 52 patients, 21 with blood collected during the TGA episode and 31 shortly thereafter. We compared these two groups after adjustment for time of blood collection. The cortisol level was significantly higher in the per-ictal group (P=0.03) and negatively correlated with the time elapsed from symptom onset (P=0.005). The results are consistent with of the hypothesis of a hyperreactivity of the hypothalamic-pituitary-adrenal axis.
短暂性全面遗忘症（TGA）可由高水平的血液皮质醇引发。我们评估了患者在 TGA 期间的皮质醇水平是否高于发作后不久。我们纳入了 52 名患者，其中 21 名患者在 TGA 发作期间采集了血液，31 名患者在发作后不久采集了血液。在调整了采血时间后，我们比较了这两组。发作期组的皮质醇水平显著升高（P=0.03），且与症状发作后时间呈负相关（P=0.005）。结果与下丘脑-垂体-肾上腺轴超反应性假说一致。
