Department of Medical Oncology, Zhuji People's Hospital of Zhejiang Province, The Zhuji affiliated Hospital of Shaoxing University, Zhuji, Zhejiang 311800, China.
Department of Pharmacy, Hangzhou Cancer Hospital, Hangzhou, Zhejiang, China.
Gene. 2020 Apr 15;734:144395. doi: 10.1016/j.gene.2020.144395. Epub 2020 Jan 25.
Studies imply the FOXP3 gene polymorphisms are engaged in the occurrence of some cancers, but the relationship between FOXP3 rs2280883 polymorphism and the hazard of colorectal cancer (CRC) is unclear. For this reason, a case-control investigation involving 365 CRC patients and 411 healthy individuals (matched by both age and gender) was taken to illustrate the underlying association. FOXP3 rs2280883 polymorphism genotyped via PCR-RELP. Data revealed this polymorphism was significantly linked to increased risk for CRC (CC versus TT, OR, 1.75; 95%CI, 1.06-2.88; P = 0.030). Subgroup analyses uncovered FOXP3 rs2280883 polymorphism intensified the risk of CRC among smokers. As for the connection between rs2280883 and clinical data of CRC, this polymorphism corelated to lymph node metastasis (CC versus TT: OR, 2.75; 95%CI, 1.35-5.62; P = 0.004) and the TNM stage. In conclusion, FOXP3 rs2280883 polymorphism is related to higher risk of CRC in a Chinese individuals. Larger-sized studies involving other races are needed.
研究表明,FOXP3 基因多态性与某些癌症的发生有关,但 FOXP3 rs2280883 多态性与结直肠癌(CRC)风险之间的关系尚不清楚。出于这个原因,进行了一项病例对照研究,涉及 365 名 CRC 患者和 411 名健康个体(按年龄和性别匹配),以阐明潜在的关联。通过 PCR-RELp 对 FOXP3 rs2280883 多态性进行基因分型。数据显示,这种多态性与 CRC 的风险增加显著相关(CC 与 TT,OR,1.75;95%CI,1.06-2.88;P=0.030)。亚组分析发现,FOXP3 rs2280883 多态性增加了吸烟者患 CRC 的风险。至于 rs2280883 与 CRC 临床数据之间的关系,这种多态性与淋巴结转移(CC 与 TT:OR,2.75;95%CI,1.35-5.62;P=0.004)和 TNM 分期有关。总之,FOXP3 rs2280883 多态性与中国人群 CRC 的风险增加有关。需要更大规模的涉及其他种族的研究。