肝硬化与心肌病的关联
Association of Cirrhosis and Cardiomyopathy.
作者信息
Sezgin Burcu, Cindoglu Cigdem, Uyanikoglu Ahmet, Yenice Necati
机构信息
Department of Internal Medicine, Sanliurfa Education Research Hospital, Sanliurfa, Turkey.
Department of Internal Medicine, Harran University, Sanliurfa, Turkey.
出版信息
Euroasian J Hepatogastroenterol. 2019 Jan-Jun;9(1):23-26. doi: 10.5005/jp-journals-10018-1291.
INTRODUCTION
We investigated association of pro-BNP, troponin-I, electrocardiography (ECG) and echocardiography (ECHO) during diagnosis and identification of cirrhotic cardiomyopathy in cirrhotic patients.
MATERIALS AND METHODS
Patients were divided into three groups as; compensated cirrhotic patients (group 1, n= 30), decompensated cirrhotic (group 2, n = 30) and control group (group 3, n = 30). ECHO, and ECG were performed, and troponin-I and levels of pro-BNP were analyzed.
RESULTS
Average age of group 1 was 46.36 ± 16 years (range 19-86), 60% were female; group 2 was 57.03 ± 13.54 years (range 22-89), 56% female; and group 3 was 49.13 ± 0.95 years (range 18-80), 56% female. A significant increase in QTc was detected in compensated cirrhotic patients compared to the control group (p <0.05). Pro-BNP levels were significantly higher (p <0.05) in the compensated cirrhotic group compared to the control group. The levels of pro-BNP were also significantly higher in the decompensated cirrhotic group compared compensated cirrhosis group and control group (p <0.001).
CONCLUSION
The increase of pro-BNP levels with severity of the disease in cirrhotic patients and the prolongation of QTc interval supports an association between these factors with cardiomyopathy.
HOW TO CITE THIS ARTICLE
Sezgin B, Cindoglu C, et al. Association of Cirrhosis and Cardiomyopathy. Euroasian J Hepatogastroenterol 2019;9(1):23-26.
引言
我们研究了在肝硬化患者诊断和鉴别肝硬化性心肌病过程中，脑钠肽前体（pro-BNP）、肌钙蛋白I、心电图（ECG）和超声心动图（ECHO）之间的关联。
材料与方法
患者被分为三组，分别为：代偿期肝硬化患者（第1组，n = 30）、失代偿期肝硬化患者（第2组，n = 30）和对照组（第3组，n = 30）。进行了超声心动图和心电图检查，并分析了肌钙蛋白I和脑钠肽前体水平。
结果
第1组的平均年龄为46.36±16岁（范围19 - 86岁），女性占60%；第2组为57.03±13.54岁（范围22 - 89岁），女性占56%；第3组为49.13±0.95岁（范围18 - 80岁），女性占56%。与对照组相比，代偿期肝硬化患者的QTc显著延长（p <0.05）。与对照组相比，代偿期肝硬化组的脑钠肽前体水平显著更高（p <0.05）。与代偿期肝硬化组和对照组相比，失代偿期肝硬化组的脑钠肽前体水平也显著更高（p <0.001）。
结论
肝硬化患者中脑钠肽前体水平随疾病严重程度增加以及QTc间期延长，支持这些因素与心肌病之间存在关联。
如何引用本文
Sezgin B, Cindoglu C, 等。肝硬化与心肌病的关联。《欧亚肝脏胃肠病学杂志》2019；9(1):23 - 26。
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