Zhao Jiancheng, Li Sai, Ren Linan, Guo Xiaozhong, Qi Xingshun
Department of Gastroenterology (JZ, LR, XG, XQ), General Hospital of Shenyang Military Area, Shenyang, China; Department of Rehabilitation (JZ), Jia He Hospital of the Liaoning University of Traditional Chinese Medicine, Shenyang, China.
Department of Cardiology (SL), No. 4 People's Hospital of Shenyang City, Shenyang, China.
Am J Med Sci. 2017 Aug;354(2):131-139. doi: 10.1016/j.amjms.2017.04.005. Epub 2017 Apr 7.
Increased pro-brain natriuretic peptide (pro-BNP) or troponin T-hypersensitivity (TnT-HSST) levels are common in liver cirrhosis. We conducted a retrospective observational study aimed to evaluate the correlation of pro-BNP and TnT-HSST levels with the clinical characteristics, laboratory data and in-hospital outcomes of patients with liver cirrhosis.
We selected cirrhotic patients admitted to our hospital between January 2011 and June 2014. All eligible patients had pro-BNP or TnT-HSST data, or both. The pro-BNP and TnT-HSST data were further divided according to the presence of cardiac diseases.
The prevalence of pro-BNP level >900pg/mL was 41.72% (63 of 151 patients). The prevalence of TnT-HSST level >0.05ng/mL was 11.22% (45 of 401 patients). In the overall analysis, pro-BNP level significantly correlated with red blood cell (RBC), platelet, ascites, blood urea nitrogen (BUN), creatinine (Cr), Child-Pugh score, model for end-stage liver disease (MELD) score and in-hospital death; TnT-HSST level significantly correlated with white blood cell, ascites, albumin (ALB), BUN, Cr, Child-Pugh score, MELD score and in-hospital death. In patients with cardiac diseases, pro-BNP level significantly correlated with RBC, ascites, BUN, Cr, Child-Pugh score and MELD score; TnT-HSST level significantly correlated with sex, ascites, white blood cell, ALB, BUN, Cr, Child-Pugh score, MELD score and in-hospital death. In patients without cardiac diseases, pro-BNP level significantly correlated with ascites, RBC, platelet, BUN, Cr, MELD score and in-hospital death; TnT-HSST level significantly correlated with age, ascites, RBC, ALB, BUN, Cr, Child-Pugh score, MELD score and in-hospital death.
Pro-BNP and TnT-HSST levels significantly correlated with the severity of liver dysfunction and in-hospital mortality in cirrhosis.
在肝硬化患者中，脑钠肽前体（pro-BNP）水平升高或肌钙蛋白T超敏反应（TnT-HSST）水平升高较为常见。我们开展了一项回顾性观察性研究，旨在评估pro-BNP和TnT-HSST水平与肝硬化患者的临床特征、实验室数据及住院结局之间的相关性。
我们选取了2011年1月至2014年6月期间入住我院的肝硬化患者。所有符合条件的患者均有pro-BNP或TnT-HSST数据，或两者皆有。根据是否存在心脏疾病对pro-BNP和TnT-HSST数据进行进一步划分。
pro-BNP水平>900pg/mL的患病率为41.72%（151例患者中的63例）。TnT-HSST水平>0.05ng/mL的患病率为11.22%（401例患者中的45例）。在总体分析中，pro-BNP水平与红细胞（RBC）、血小板、腹水、血尿素氮（BUN）、肌酐（Cr）、Child-Pugh评分、终末期肝病模型（MELD）评分及住院死亡显著相关；TnT-HSST水平与白细胞、腹水、白蛋白（ALB）、BUN、Cr、Child-Pugh评分、MELD评分及住院死亡显著相关。在有心脏疾病的患者中，pro-BNP水平与RBC、腹水、BUN、Cr、Child-Pugh评分及MELD评分显著相关；TnT-HSST水平与性别、腹水、白细胞、ALB、BUN、Cr、Child-Pugh评分、MELD评分及住院死亡显著相关。在无心脏疾病的患者中，pro-BNP水平与腹水、RBC、血小板、BUN、Cr、MELD评分及住院死亡显著相关；TnT-HSST水平与年龄、腹水、RBC、ALB、BUN、Cr、Child-Pugh评分、MELD评分及住院死亡显著相关。
pro-BNP和TnT-HSST水平与肝硬化患者肝功能障碍的严重程度及住院死亡率显著相关。
