CAS Key Laboratory of Soft Matter Chemistry and Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China.
Org Biomol Chem. 2020 Feb 14;18(6):1057-1072. doi: 10.1039/c9ob02667c. Epub 2020 Jan 28.
Quaternary ammonium salts are readily prepared and show good reactivity in various organic transformations via C-N bond cleavage. In this review we summarize reactions of aryl, benzyl, allyl and propargyl quaternary ammonium salts including cross-coupling with organometallic reagents, as arylation or benzylation reagents in C-H functionalization, reductive deamination, reductive coupling, nucleophilic substitution, carboxylation with CO, and carbonylation with CO to construct C-C, C-H and C-heteroatom bonds.
季铵盐易于制备，并通过 C-N 键的断裂在各种有机转化中表现出良好的反应活性。在这篇综述中，我们总结了芳基、苄基、烯丙基和炔丙基季铵盐的反应，包括与有机金属试剂的交叉偶联反应，作为芳基化或苄基化试剂在 C-H 功能化中的应用，还原脱氨反应、还原偶联反应、亲核取代反应、与 CO 的羧化反应以及与 CO 的羰基化反应，以构建 C-C、C-H 和 C-杂原子键。
