Biomedical Engineering, Dwight Look College of Engineering , Texas A&M University , College Station , Texas 77843 , United States.
Material Science and Engineering, Dwight Look College of Engineering , Texas A&M University , College Station , Texas 77843 , United States.
ACS Appl Mater Interfaces. 2020 Feb 5;12(5):5319-5344. doi: 10.1021/acsami.9b17801. Epub 2020 Jan 28.
Regenerative medicine leverages the innate potential of the human body to efficiently repair and regenerate damaged tissues using engineered biomaterials. By designing responsive biomaterials with the appropriate biophysical and biochemical characteristics, cellular response can be modulated to direct tissue healing. Recently, inorganic biomaterials have been shown to regulate cellular responses including cell-cell and cell-matrix interactions. Moreover, ions released from these mineral-based biomaterials play a vital role in defining cell identity, as well as driving tissue-specific functions. The intrinsic properties of inorganic biomaterials, such as the release of bioactive ions (e.g., Ca, Mg, Sr, Si, B, Fe, Cu, Zn, Cr, Co, Mo, Mn, Au, Ag, V, Eu, and La), can be leveraged to induce phenotypic changes in cells or modulate the immune microenvironment to direct tissue healing and regeneration. Biophysical characteristics of biomaterials, such as topography, charge, size, electrostatic interactions, and stiffness can be modulated by addition of inorganic micro- and nanoparticles to polymeric networks have also been shown to play an important role in their biological response. In this Review, we discuss the recent emergence of inorganic biomaterials to harness the innate regenerative potential of the body. Specifically, we will discuss various biophysical or biochemical effects of inorganic-based materials in directing cellular response for regenerative medicine applications.
再生医学利用人体的固有潜力，通过工程生物材料高效修复和再生受损组织。通过设计具有适当物理化学特性的响应性生物材料，可以调节细胞反应来指导组织愈合。最近，无机生物材料已被证明可以调节细胞反应，包括细胞-细胞和细胞-基质相互作用。此外，这些基于矿物质的生物材料释放的离子在确定细胞特性以及驱动组织特异性功能方面发挥着重要作用。无机生物材料的固有特性，如释放具有生物活性的离子（例如 Ca、Mg、Sr、Si、B、Fe、Cu、Zn、Cr、Co、Mo、Mn、Au、Ag、V、Eu 和 La），可以被利用来诱导细胞表型变化或调节免疫微环境，以指导组织愈合和再生。生物材料的物理特性，如形貌、电荷、大小、静电相互作用和刚度，可以通过添加无机纳米粒子和微粒子到聚合物网络中来调节，这些特性也被证明在其生物学反应中起着重要作用。在这篇综述中，我们讨论了无机生物材料在利用身体固有再生潜力方面的最新进展。具体来说，我们将讨论各种基于无机的材料在指导细胞反应以用于再生医学应用方面的生物物理或生化效应。
