选择性抗血清素能药物酮色林对人体肛管压力的影响。

Effect of ketanserin, a selective antiserotoninergic drug, on human anal canal pressure.

作者信息

Neri M, Marzio L, De Angelis C, Pieramico O, Mezzetti A, Cuccurullo F

机构信息

Institute of Medical Physiopathology, University of Chieti, Italy.

出版信息

Int J Colorectal Dis. 1988 Nov;3(4):219-21. doi: 10.1007/BF01660718.

DOI:10.1007/BF01660718

PMID:3198992

Abstract

The effect of Ketanserin, a new antiserotoninergic drug, on human anal pressure in vivo was investigated. Anal pressure was recorded continuously in 14 normal subjects by a low-compliance water perfused probe with two recording points at the sphincter level. After a 30-min basal tracing Ketanserin (10 mg IV as bolus) or placebo was administered in a double blind manner, and the recording continued for 1 h. The results show that Ketanserin induced a 30% fall in anal pressure soon after its administration which was statistically significant when compared with the placebo (p less than 0.01). This effect lasted up to 40 min of recording and was followed by a return to control values within 1 h.

摘要

研究了新型抗血清素能药物酮色林对人体活体肛门压力的影响。通过低顺应性水灌注探头在14名正常受试者中连续记录肛门压力，该探头在括约肌水平有两个记录点。在进行30分钟的基础记录后，以双盲方式给予酮色林（静脉推注10毫克）或安慰剂，并继续记录1小时。结果表明，酮色林给药后不久可使肛门压力下降30%，与安慰剂相比具有统计学意义（p<0.01）。这种效应持续到记录的40分钟，随后在1小时内恢复到对照值。