Siddiqui Mohamed Tausif, Bilal Mohammad, Singh Amandeep, Olivier-Cabrera Sarah, Lebovics Edward, Schorr-Lesnick Beth, Dworkin Brad, Kirby Donald F
Department of Gastroenterology, Hepatology and Nutrition, Digestive Disease and Surgery Institute, Cleveland Clinic, Cleveland, Ohio.
Department of Gastroenterology & Hepatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
Neurogastroenterol Motil. 2020 Apr;32(4):e13806. doi: 10.1111/nmo.13806. Epub 2020 Jan 28.
Cyclic vomiting syndrome (CVS) is a functional gastrointestinal disorder which leads to multiple hospitalizations and causes significant impairment of quality of life. Cannabis use is common in patients with CVS, and there are limited data on the national trends in the prevalence of its use in the United States.
We used the National Inpatient Sample (NIS) database from 2005 to 2014 and identified hospitalizations with a primary diagnosis of CVS by utilizing the International Classification of Diseases, 9th revision Clinical Modification (ICD-9 CM) coding system. The primary objective of the study was to analyze the prevalence and trends in cannabis use in CVS patients. We also assessed healthcare resource utilization associated with cannabis use.
A total of 129 090 hospitalizations with a primary diagnosis of CVS were identified and included in the study. In the United States, the overall rate of cannabis use among these patients was 104 per 1000 hospitalizations (N = 13 460). Over the last decade, the prevalence of cannabis use increased by 10-fold, from 2.2% in 2005 to 21.2% in 2014.
Our analysis of the national database suggests that nearly 1 in 5 CVS hospitalizations have concurrent cannabis use. This prevalence is significantly rising over the last decade, perhaps due to changing legislation and increased utilization of cannabis. Age younger than 35, male gender, African American and Native American race, personal history of alcohol abuse and tobacco use were some of the strongest predictors of cannabis use.
周期性呕吐综合征（CVS）是一种功能性胃肠疾病，会导致多次住院，并严重损害生活质量。大麻在CVS患者中使用很普遍，而关于美国其使用流行率的全国趋势的数据有限。
我们使用了2005年至2014年的全国住院患者样本（NIS）数据库，并通过利用国际疾病分类第九版临床修订本（ICD - 9 CM）编码系统确定了以CVS为主要诊断的住院病例。该研究的主要目的是分析CVS患者中大麻使用的流行率和趋势。我们还评估了与大麻使用相关的医疗资源利用情况。
共确定了129090例以CVS为主要诊断的住院病例并纳入研究。在美国，这些患者中大麻使用的总体发生率为每1000例住院病例中有104例（N = 13460）。在过去十年中，大麻使用的流行率增长了10倍，从2005年的2.2%增至2014年的21.2%。
我们对全国数据库的分析表明，近五分之一的CVS住院病例同时使用大麻。在过去十年中，这一流行率显著上升，可能是由于立法变化和大麻使用增加所致。年龄小于35岁、男性、非裔美国人和美洲原住民种族、有酒精滥用和烟草使用个人史是大麻使用的一些最强预测因素。
