Zvizdic Zlatan, Milisic Emir, Jonuzi Asmir, Terzic Sabina, Zvizdic Denisa
Department of Clinic of Pediatric Surgery, University Clinical Center Sarajevo, Sarajevo, Bosnia and Herzegovina.
Department of Pediatric Clinic, Neonatal Intensive Care Unit, University Clinical Center Sarajevo, Sarajevo, Bosnia and Herzegovina.
Turk J Pediatr. 2019;61(4):513-519. doi: 10.24953/turkjped.2019.04.007.
Zvizdic Z, Milisic E, Jonuzi A, Terzic S, Zvizdic D. The contribution of morphine sulfate to the development of necrotizing enterocolitis in preterm infants: a matched case-control study. Turk J Pediatr 2019; 61: 513-519. The aim of the study was to determine whether morphine sulfate administration is associated with an increased risk of necrotizing enterocolitis (NEC) in preterm infants supported by mechanical ventilation due to respiratory failure. The matched case-control retrospective study was carried out at the Neonatal Intensive Care Unit (NICU) of the University Clinical Center Sarajevo, on 122 preterm infants classified into total NEC group and control group. The total NEC group was further divided into medical NEC and surgical NEC subgroups. The association between the use and duration of morphine sulfate infusion and the development of NEC was evaluated in both unadjusted and adjusted analysis. Preterm infants who developed NEC were on mechanical ventilation more frequently compared to premature infants without signs of NEC (Mann- Whitney U test; p=0.0031). A positive correlation between the frequency of receiving morphine sulfate and the development of NEC was observed (Chi square test of independence; p=0.0001). The risk of NEC in preterm infants was increased by the use of morphine sulfate. Validation of this observation in other populations is warranted.
兹维兹迪奇Z、米利西奇E、约努齐A、特尔济奇S、兹维兹迪奇D。硫酸吗啡对早产儿坏死性小肠结肠炎发生发展的影响：一项配对病例对照研究。《土耳其儿科学杂志》2019年；61:513 - 519。本研究的目的是确定对于因呼吸衰竭而接受机械通气支持的早产儿，使用硫酸吗啡是否会增加坏死性小肠结肠炎（NEC）的风险。该配对病例对照回顾性研究在萨拉热窝大学临床中心新生儿重症监护病房（NICU）对122例早产儿进行，这些早产儿被分为NEC总病例组和对照组。NEC总病例组进一步分为内科NEC亚组和外科NEC亚组。在未调整和调整分析中均评估了硫酸吗啡输注的使用及持续时间与NEC发生之间的关联。与无NEC体征的早产儿相比，发生NEC的早产儿接受机械通气的频率更高（曼 - 惠特尼U检验；p = 0.0031）。观察到接受硫酸吗啡的频率与NEC的发生之间存在正相关（独立性卡方检验；p = 0.0001）。使用硫酸吗啡会增加早产儿发生NEC的风险。有必要在其他人群中验证这一观察结果。
