癌症化疗诱导淋巴因子激活的杀伤样细胞
Induction of lymphokine-activated killer-like cells by cancer chemotherapy.
作者信息
Kiyohara T, Taniguchi K, Kubota S, Koga S, Sakuragi T, Saitoh Y
机构信息
Department of Pathology, Nagasaki University, Japan.
出版信息
J Exp Med. 1988 Dec 1;168(6):2355-60. doi: 10.1084/jem.168.6.2355.
Abstract
Natural cell-mediated cytotoxicity against NK-resistant target tumor cells was found in the peripheral blood of tumor-bearing patients approximately 1 mo after combined chemotherapy. The recognition specificity of these effector cells was broad and had no restriction. From the experiments of negative selection with mAbs and complements, these newly developed killer cells after chemotherapy were thought to be LAK-like cells. Contribution of these LAK-like cells to the mechanism of action of anticancer drugs remains to be clarified.
摘要
在接受联合化疗约1个月后，在荷瘤患者的外周血中发现了针对NK抗性靶肿瘤细胞的天然细胞介导的细胞毒性。这些效应细胞的识别特异性广泛且无限制。通过单克隆抗体和补体的阴性选择实验，化疗后新产生的这些杀伤细胞被认为是LAK样细胞。这些LAK样细胞在抗癌药物作用机制中的作用仍有待阐明。
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