Restivo Vincenzo, Costantino Claudio, Amato Livia, Candiloro Stefania, Casuccio Alessandra, Maranto Marianna, Marrella Alessandro, Palmeri Sara, Pizzo Stefano, Vitale Francesco, Amodio Emanuele
Department of Health Promotion, Maternal and Infant Care, Internal Medicine and Medical Specialties, "G. D'Alessandro", University of Palermo, Via del Vespro 133, Palermo 90127, Italy.
Vaccines (Basel). 2020 Jan 26;8(1):47. doi: 10.3390/vaccines8010047.
In light of the implementation of human papillomavirus (HPV) prevention strategies, epidemiological studies in different geographical areas are required in order to assess the impact of HPV-related diseases. The purpose of the present study was to describe the burden of HPV-related hospitalizations in Sicily. A retrospective observational study estimated 43,531 hospitalizations attributable to HPV from 2007 to 2017. During the observed period, there was a decrease for all HPV-related conditions with a higher reduction, among neoplasms, for cervical cancer (annual percent change (APC) = -9.9%, p < 0.001). The median age for cervical cancer was 45 years old, with an increasing value from 43 to 47 years (p < 0.001). The age classes with greater decreases in hospital admissions for invasive cancers were women aged 35 years or more (APC range from -5.5 to -9.86) and 25-34 years old (APC = -11.87, p < 0.001) for women with cervical carcinoma in situ. After ten years for vaccine introduction and sixteen years for cervical cancer screening availability, a relatively large decrease in hospital admissions for cervical cancer and other HPV-related diseases in Sicily was observed. Some clinical characteristics of hospitalization, such as increasing age, are suggestive clues for the impact of preventive strategies, but further research is needed to confirm this relationship.
鉴于人乳头瘤病毒（HPV）预防策略的实施，需要在不同地理区域开展流行病学研究，以评估HPV相关疾病的影响。本研究的目的是描述西西里岛HPV相关住院病例的负担。一项回顾性观察研究估计，2007年至2017年期间，归因于HPV的住院病例有43531例。在观察期内，所有HPV相关疾病的病例数均有所下降，在肿瘤中，宫颈癌下降幅度更大（年变化百分比（APC）=-9.9%，p<0.001）。宫颈癌的中位年龄为45岁，从43岁增加到47岁（p<0.001）。侵袭性癌症住院人数下降幅度较大的年龄组为35岁及以上的女性（APC范围为-5.5至-9.86），原位宫颈癌女性中25-34岁年龄组的下降幅度也较大（APC=-11.87，p<0.001）。在引入疫苗十年和宫颈癌筛查普及十六年后，观察到西西里岛宫颈癌和其他HPV相关疾病的住院人数有较大幅度下降。住院的一些临床特征，如年龄增加，是预防策略产生影响的提示线索，但需要进一步研究来证实这种关系。
