Academic Section of Vascular Surgery, Department of Surgery and Cancer, Imperial College London, UK.
Imperial Vascular Unit, Imperial College Healthcare NHS Trust, London, UK.
Phlebology. 2020 Aug;35(7):520-523. doi: 10.1177/0268355520901662. Epub 2020 Jan 28.
Non-thermal non-tumescent methods for varicose vein treatment have rapidly gained popularity in recent years due to clinical efficacy comparable to other endovenous methods, but with a superior safety and tolerability profile. Cyanoacrylate is an adhesive that rapidly polymerises during endovenous treatment to cause rapid occlusion of veins and initiate vein fibrosis.
Cyanoacrylate glue treatment is known to cause complications such as phlebitis, cellulitis and deep vein thrombosis in rare instances. We present the first reported case of cyanoacrylate extravasation with chronic foreign body reaction in a patient nine months after initial treatment.
We discuss the aetiology of this complication, its treatment, patient outcome and its significance to both clinicians and patients.
Cyanoacrylate glue embolisation can, in rare instances, lead to extravasation and chronic foreign body reaction, necessitating surgical intervention. The relative novelty of cyanoacrylate glue embolisation in the treatment of varicose veins requires clinicians to monitor for rare complications during its use in clinical practice. Patients should be aware of the rare risk of glue extravasation and foreign body reaction for fully informed consent prior to treatment.
近年来，由于非热非肿胀方法治疗静脉曲张的临床疗效可与其他静脉内方法相媲美，但其安全性和耐受性更佳，因此迅速受到欢迎。氰基丙烯酸酯是一种粘合剂，在静脉内治疗过程中迅速聚合，导致静脉迅速闭塞并引发静脉纤维化。
已知氰基丙烯酸酯胶处理会在极少数情况下引起静脉炎、蜂窝织炎和深静脉血栓形成等并发症。我们报告了首例患者在初次治疗 9 个月后出现氰基丙烯酸酯外渗伴慢性异物反应的病例。
我们讨论了这种并发症的病因、治疗、患者结局及其对临床医生和患者的意义。
氰基丙烯酸酯胶栓塞在极少数情况下可导致外渗和慢性异物反应，需要手术干预。氰基丙烯酸酯胶栓塞在静脉曲张治疗中的相对新颖性要求临床医生在临床实践中使用时监测罕见的并发症。在治疗前，患者应充分了解胶外渗和异物反应的罕见风险，并获得知情同意。
