回波时间对 T2 加权图像前列腺癌检测的影响。
Effect of Echo Times on Prostate Cancer Detection on T2-Weighted Images.
机构信息
Department of Radiology, University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637; Sanford J. Grossman Center of Excellence in Prostate Imaging and Image Guided Therapy, University of Chicago, Chicago, Illinois.
Department of Radiology, University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637.
出版信息
Acad Radiol. 2020 Nov;27(11):1555-1563. doi: 10.1016/j.acra.2019.12.014. Epub 2020 Jan 26.
PURPOSE
To compare the effect of different echo times (TE) on the detection of prostate cancer (PCa) on T2-weighted MR images.
MATERIALS AND METHODS
This study recruited patients (n = 38) with histologically confirmed PCa who underwent preoperative 3T MRI. Three radiologists independently marked region on interests (ROIs) on suspected PCa lesions on T2-weighted images at different TEs: 90, 150, and 180 ms obtained with Turbo Spin Echo imaging protocol with multiple echoes. The ROIs were assigned a value 1-5 indicating the reviewer's confidence in accurately detecting PCa. These ROIs were compared to histologically confirmed PCa (n = 95) on whole mount prostatectomy sections to calculate sensitivity, positive predictive value (PPV), and confidence score.
RESULTS
Two radiologists (R1, R2) showed significantly increased sensitivity for PCa detection at 180 ms TE compared to 90 ms (R1: 43.2, 50.5, 50.5%, R2: 45.3, 44.2, 53.7% at TE of 90, 150, 180 ms, respectively) (p = 0.048, 0.033 for R1 and R2). Sensitivity was similar for radiologist 3 (45.3%-46.3%) at different TE values (p = 0.953). No significant difference in the PPV (R1: 64.1%-70.6%, R2: 46.7%-56.0%, R3: 70.5%-81.5%) and the confidence score assigned (R1: 4.6-4.8, R2: 4.6-4.8 R3: 4.3-4.4) was found for either of the radiologists.
CONCLUSION
Our results suggest improved detection of PCa with similar PPV and confidence scores when higher TE values are utilized for T2-weighted image acquisition.
目的
比较不同回波时间（TE）对 T2 加权磁共振成像中前列腺癌（PCa）检测的影响。
材料与方法
本研究招募了 38 名经组织学证实患有 PCa 的患者，这些患者在术前均接受了 3T MRI 检查。3 名放射科医生分别在 T2 加权图像上对可疑 PCa 病变的感兴趣区域（ROI）进行标记，这些图像是通过多回波 Turbo Spin Echo 成像协议获得的，TE 分别为 90、150 和 180ms。ROI 的赋值范围为 1-5，用于表示观察者准确检测 PCa 的信心程度。这些 ROI 与整个前列腺切除术标本中的组织学证实的 PCa（n=95）进行比较，以计算敏感性、阳性预测值（PPV）和置信评分。
结果
两名放射科医生（R1、R2）在 180ms TE 时检测 PCa 的敏感性明显高于 90ms TE（R1：43.2%、50.5%、50.5%，R2：45.3%、44.2%、53.7%，TE 分别为 90、150、180ms）（p=0.048，0.033 对于 R1 和 R2）。放射科医生 3 的敏感性在不同 TE 值时相似（45.3%-46.3%）（p=0.953）。两位放射科医生的 PPV（R1：64.1%-70.6%，R2：46.7%-56.0%，R3：70.5%-81.5%）和分配的置信评分（R1：4.6-4.8，R2：4.6-4.8 R3：4.3-4.4）均无显著差异。
结论
本研究结果表明，在 T2 加权图像采集时使用较高的 TE 值可以提高 PCa 的检测率，同时具有相似的 PPV 和置信评分。
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