Manwarring L, O'Connell D L, Bhagwandeen B S, Zardawi I M, Dobson A J
Faculty of Medicine, University of Newcastle, New South Wales, Australia.
J Pathol. 1988 Oct;156(2):111-7. doi: 10.1002/path.1711560205.
Luminal narrowing was assessed in 238 transverse segments obtained from coronary arteries removed at postmortem. In each segment, narrowing was assessed by gross visual estimation before and after fixation, and on histological sections by stereological point counting and computer-assisted planimetry. Computer-assisted planimetry was found to be accurate and reliable but the equipment needed is expensive, and requires specialized software and an experienced user. Morphometric measurement by stereologic point counting was accurate, rapid, simple, and inexpensive. In comparison with computer-assisted planimetry visual estimation was found to be neither accurate nor reliable. Our results indicate point counting as the method of choice for assessment of coronary artery luminal narrowing by atherosclerosis.
对238个取自尸检时移除的冠状动脉的横切片段进行了管腔狭窄评估。在每个片段中，在固定前后通过大体视觉估计进行狭窄评估，并在组织学切片上通过体视学点计数和计算机辅助平面测量法进行评估。发现计算机辅助平面测量法准确可靠，但所需设备昂贵，且需要专业软件和有经验的用户。通过体视学点计数进行形态测量准确、快速、简单且成本低廉。与计算机辅助平面测量法相比，视觉估计既不准确也不可靠。我们的结果表明，点计数法是评估动脉粥样硬化所致冠状动脉管腔狭窄的首选方法。
