Determination and prediction of permeability across intestinal epithelial cell monolayer of a diverse range of industrial chemicals/drugs for estimation of oral absorption as a putative marker of hepatotoxicity.

Apparent permeability coefficients ( ) across a human intestinal epithelial Caco-2 cell monolayer were measured for a range of industrial/drug chemicals. A predictive equation for determining values of fifty-six substances was set up using multivariate regression analysis based on -estimated physicochemical properties (molecular weights and water distribution coefficients for apical and basal pH environments) ( = 0.77,  <  0.01). Predicted log values of a secondary set of 34 compounds were correlated with the measured values. Under the medicinal log values associated with their reported fraction absorbed, a significant inverse non-linear correlation was found between the logarithmic transformed values of observed values and reported hepatic no-observed-effect levels of industrial chemicals ( = -0.55,  <  0.01, n = 29). determination and/or prediction of permeability across intestinal cells could be effective for estimating oral absorption as a putative indicator for hepatotoxicity.