儿童粪便微生物群移植不会显著改变体重指数。
Fecal microbiota transplantation in children does not significantly alter body mass index.
作者信息
Xi Dong, Michail Sonia
机构信息
Division of Gastroenterology, Hepatology and Nutrition, Miller Children's Hospital and the University of Southern California Keck School of Medicine, Los Angeles, CA, USA.
出版信息
Transl Pediatr. 2019 Dec;8(5):398-401. doi: 10.21037/tp.2019.09.05.
BACKGROUND
Fecal microbiota transplantation (FMT) is nowadays a promising therapy for Clostridium difficile infection (CDI) and a potential treatment for ulcerative colitis. However, it is still unclear whether the changes in intestinal microbiome will affect energy homeostasis or metabolism. This brings an intriguing question whether FMT from healthy donors affects recipient's body mass index (BMI).
METHODS
In our randomized placebo-controlled study children patients with CDI or ulcerative colitis were randomly divided into control and FMT groups. The change of post-FMT BMI percentile at 1, 3, 6, 12 months was calculated. The age range of CDI cohort was 1 to 17 years, while the range was 8 to 21 years for ulcerative colitis cohort.
RESULTS
We found that the BMI percentile was insignificantly changed by ‒0.7%, ‒1.8%, 1.3%, 4.6% in CDI, while by 3.6%, ‒3.3%, 3.7%, 7.1% in ulcerative colitis at 1, 3, 6, 12 months after FMT ("‒" means decrease).
CONCLUSIONS
We concluded that FMT from healthy donors does not significantly alter BMI in children with CDI and ulcerative colitis over 12 months.
背景
粪便微生物群移植（FMT）如今是治疗艰难梭菌感染（CDI）的一种有前景的疗法，也是治疗溃疡性结肠炎的一种潜在疗法。然而，肠道微生物组的变化是否会影响能量平衡或代谢仍不清楚。这就引出了一个有趣的问题，即来自健康供体的FMT是否会影响受体的体重指数（BMI）。
方法
在我们的随机安慰剂对照研究中，患有CDI或溃疡性结肠炎的儿童患者被随机分为对照组和FMT组。计算FMT后1、3、6、12个月时BMI百分位数的变化。CDI队列的年龄范围为1至17岁，而溃疡性结肠炎队列的年龄范围为8至21岁。
结果
我们发现，在FMT后1、3、6、12个月，CDI患者的BMI百分位数分别有微不足道的变化，为-0.7%、-1.8%、1.3%、4.6%，而溃疡性结肠炎患者的变化分别为3.6%、-3.3%、3.7%、7.1%（“-”表示下降）。
结论
我们得出结论，来自健康供体的FMT在12个月内不会显著改变患有CDI和溃疡性结肠炎的儿童的BMI。
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