在……中，IKK复合物的选择性自噬降解由Kenny/IKKγ介导以控制炎症。 （你提供的原文中“in”后面缺少具体内容）
Selective autophagic degradation of the IKK complex in is mediated by Kenny/IKKγ to control inflammation.
作者信息
Jacomin Anne-Claire, Nezis Ioannis P
机构信息
School of Life Sciences, University of Warwick, Coventry, UK.
出版信息
Mol Cell Oncol. 2019 Nov 6;7(1):1682309. doi: 10.1080/23723556.2019.1682309. eCollection 2020.
Implication of autophagy in the downregulation of immune signaling pathways through the degradation of their components constitutes an emerging field of investigation. Our work showed that the selective interaction of protein Kenny/IKKγ (CG16910) with the autophagic machinery is required for the degradation of the I-kappa B kinase complex. This regulatory mechanism is essential for the downregulation of the immune deficiency (IMD) pathway in response to commensal microbiota to prevent inflammation.
自噬通过降解免疫信号通路的组成成分从而下调这些通路，这一过程构成了一个新兴的研究领域。我们的研究表明，蛋白质Kenny/IKKγ（CG16910）与自噬机制的选择性相互作用是I-κB激酶复合物降解所必需的。这种调节机制对于响应共生微生物群而下调免疫缺陷（IMD）通路以预防炎症至关重要。
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