长链非编码RNA在癌症精准医学中的新兴作用。
Emerging role of long non-coding RNAs in cancer precision medicine.
作者信息
Nath Aritro, Huang R Stephanie
机构信息
Department of Medical Oncology and Therapeutics Research, City of Hope, Duarte, LA, USA.
Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, USA.
出版信息
Mol Cell Oncol. 2019 Nov 10;7(1):1684130. doi: 10.1080/23723556.2019.1684130. eCollection 2020.
Abstract
A vast majority of the human genome encodes long non-coding RNAs (lncRNAs) as compared to protein-coding genes (PCGs). But most efforts to determine biomarkers of anticancer drug response have focused entirely on PCGs. Comprehensive investigation of lncRNAs and drug response demonstrates that lncRNAs are indeed crucial biomarkers of drug response.
摘要
与蛋白质编码基因（PCGs）相比，人类基因组中的绝大多数编码长链非编码RNA（lncRNAs）。但大多数确定抗癌药物反应生物标志物的研究完全集中在PCGs上。对lncRNAs和药物反应的全面研究表明，lncRNAs确实是药物反应的关键生物标志物。
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