[高频节律性经颅磁刺激治疗青年内源性抑郁症的疗效]
[The effectiveness of high-frequency rhythmic transcranial magnetic stimulation in endogenous depressive disorders in youth].
作者信息
Pomytkin A N, Kaleda V G, Klochkova I V, Lebedeva I S
机构信息
Mental Health Research Center, Moscow, Russia.
出版信息
Zh Nevrol Psikhiatr Im S S Korsakova. 2019;119(12):38-45. doi: 10.17116/jnevro201911912138.
AIM
To search for neurophysiological predictors of the effectiveness of rhythmic transcranial magnetic stimulation (rTMS) of the left dorsolateral prefrontal cortex in patients with depressive disorder of various nosology.
MATERIAL AND METHODS
Thirty-four young male patients with protracted treatment resistant depression were studied using psychopathological, psychometric methods and encephalography. A search for predictors of therapeutic efficacy was carried out in a wide range of neurophysiological indicators using different high-frequency rTMS protocols (10 Hz and 20 Hz)..
RESULTS AND CONCLUSION
The most significant changes were obtained using rTMS with a frequency of 20 Hz. A favorable effect of treatment was correlated with higher spectral power of the alpha- and beta 1-rhythm bands in EEG.
目的
寻找不同分类学的抑郁症患者中，左侧背外侧前额叶皮质节律性经颅磁刺激（rTMS）有效性的神经生理学预测指标。
材料与方法
采用精神病理学、心理测量方法和脑电描记法对34例患有持续性难治性抑郁症的年轻男性患者进行研究。使用不同的高频rTMS方案（10Hz和20Hz），在广泛的神经生理学指标中寻找治疗效果的预测指标。
结果与结论
使用频率为20Hz的rTMS获得了最显著的变化。治疗的良好效果与脑电图中α和β1节律带的更高频谱功率相关。
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