Shanghai Key Laboratory of Functional Materials Chemistry, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
Chem Commun (Camb). 2020 Feb 25;56(16):2415-2418. doi: 10.1039/d0cc00142b.
An entirely biodegradable nano-photosensitizer platform (PPE-FP2) was fabricated by conjugating the photosensitizer TFPC to hydrophilic polyphosphoesters (PPEs) for efficiently liberating photosensitizers at the tumor site. The complete biodegradability of PPE-FP2 avoided residual nanoparticles in vivo after therapy, realizing reliable and effective photodynamic therapy.
一种完全可生物降解的纳米光敏剂平台（PPE-FP2）是通过将光敏剂 TFPC 与亲水性聚磷酸酯（PPEs）偶联来制备的，可在肿瘤部位有效释放光敏剂。PPE-FP2 的完全可生物降解性避免了治疗后体内残留的纳米颗粒，实现了可靠有效的光动力疗法。
