亲水性聚磷酸酯-氟氯菁缀合物作为一种完全可生物降解的纳米光敏剂用于可靠且高效的光动力疗法。
Hydrophilic polyphosphoester-conjugated fluorinated chlorin as an entirely biodegradable nano-photosensitizer for reliable and efficient photodynamic therapy.
机构信息
Shanghai Key Laboratory of Functional Materials Chemistry, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
出版信息
Chem Commun (Camb). 2020 Feb 25;56(16):2415-2418. doi: 10.1039/d0cc00142b.
PMID:31994584
Abstract
An entirely biodegradable nano-photosensitizer platform (PPE-FP2) was fabricated by conjugating the photosensitizer TFPC to hydrophilic polyphosphoesters (PPEs) for efficiently liberating photosensitizers at the tumor site. The complete biodegradability of PPE-FP2 avoided residual nanoparticles in vivo after therapy, realizing reliable and effective photodynamic therapy.
摘要
一种完全可生物降解的纳米光敏剂平台（PPE-FP2）是通过将光敏剂 TFPC 与亲水性聚磷酸酯（PPEs）偶联来制备的，可在肿瘤部位有效释放光敏剂。PPE-FP2 的完全可生物降解性避免了治疗后体内残留的纳米颗粒，实现了可靠有效的光动力疗法。
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