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带瓣小管道在诺伍德式姑息手术中对体心室-肺动脉分流的影响。

The effect of a valved small conduit on systemic ventricle-pulmonary artery shunt in the Norwood-type palliation.

作者信息

Fujita Shuhei, Yamagishi Masaaki, Maeda Yoshinobu, Itatani Keiichi, Asada Satoshi, Hongu Hisayuki, Yamashita Eijiro, Takayanagi Yuji, Nakatsuji Hiroki, Yaku Hitoshi

机构信息

Department of Pediatric Cardiovascular Surgery, Children's Medical Center, Kyoto Prefectural University of Medicine, Kyoto, Japan.

Division of Cardiovascular Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.

出版信息

Eur J Cardiothorac Surg. 2020 Jun 1;57(6):1105-1112. doi: 10.1093/ejcts/ezz377.

Abstract

OBJECTIVES

The aim of this study was to clarify the impact of valved systemic ventricle-pulmonary artery (SV-PA) shunt on outcomes after stage-1 Norwood-type palliation (NP) compared with the modified Blalock-Taussig shunt.

METHODS

Consecutive patients who underwent NP between 2003 and 2019 were enrolled. SV-PA shunts using the expanded polytetrafluoroethylene valved conduit were implanted in 18 patients (valved SV-PA group), and another 18 patients underwent modified Blalock-Taussig shunt during NP (modified Blalock-Taussig shunt group). All valved conduits were made in our institution in advance.

RESULTS

No differences in baseline characteristics were found between the groups, except for shunt size. During a median 2.9 (interquartile range 0.4-6.4, maximum 14.2) years of follow-up, 8 (22.2%) patients died across both groups. There were no statistically significant differences in early mortality (5.5% vs 11.1%, P = 0.55) and overall survival rates at 5 years (80.8% vs 71.4%, P = 0.48) in the valved SV-PA and modified Blalock-Taussig shunt groups. No statistically significant difference was observed in the frequency of interventions between the groups (31% vs 33%, P = 1.0). At the time of the bidirectional Glenn procedure, the systemic ventricular end-diastolic volume index was significantly lower (84 ± 24 vs 106 ± 31 ml/m2, P = 0.05) and the ejection fraction was significantly greater (62 ± 8% vs 55 ± 9%, P = 0.03) in the valved SV-PA group. There was no statistically significant difference in the pulmonary artery index (228 ± 85 vs 226 ± 60 mm2/m2, P = 0.92).

CONCLUSIONS

A valved SV-PA shunt using an expanded polytetrafluoroethylene valved conduit was associated with preserved ventricular function after NP and did not impair pulmonary artery growth by controlling pulmonary regurgitation.

摘要

目的

本研究旨在阐明带瓣体肺静脉分流术(SV-PA)与改良布莱洛克-陶西格分流术相比,对一期诺伍德式姑息手术(NP)术后结局的影响。

方法

纳入2003年至2019年间接受NP手术的连续患者。18例患者植入了使用膨体聚四氟乙烯带瓣导管的SV-PA分流术(带瓣SV-PA组),另外18例患者在NP手术期间接受了改良布莱洛克-陶西格分流术(改良布莱洛克-陶西格分流术组)。所有带瓣导管均预先在本机构制作。

结果

除分流大小外,两组间基线特征无差异。在中位2.9年(四分位间距0.4 - 6.4年,最长14.2年)的随访期间,两组共有8例(22.2%)患者死亡。带瓣SV-PA组与改良布莱洛克-陶西格分流术组的早期死亡率(5.5%对11.1%,P = 0.55)和5年总生存率(80.8%对71.4%,P = 0.48)无统计学显著差异。两组间干预频率无统计学显著差异(31%对33%,P = 1.0)。在双向格林手术时,带瓣SV-PA组的体心室舒张末期容积指数显著更低(84±24对106±31 ml/m²,P = 0.05),射血分数显著更高(62±8%对55±9%,P = 0.03)。肺动脉指数无统计学显著差异(228±85对226±60 mm²/m²,P = 0.92)。

结论

使用膨体聚四氟乙烯带瓣导管的带瓣SV-PA分流术与NP术后心室功能保留相关,且通过控制肺反流未损害肺动脉生长。

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