Norton Thoracic Institute, St. Joseph's Hospital and Medical Center, Phoenix, Arizona, USA.
Creighton University School of Medicine, Phoenix Regional Campus, Phoenix, Arizona, USA.
Dig Dis. 2020;38(5):355-363. doi: 10.1159/000505123. Epub 2020 Jan 29.
BACKGROUND: Hypercontractile motility of the esophagus is occasionally noted on high-resolution manometry (HRM), but its clinical correlations are unclear. We compared symptom severity and clinical presentation of patients with hypercontractile motility of the esophagus. METHODS: This was a retrospective cohort study. We queried a prospectively maintained database for patients who underwent esophageal function testing from October 1, 2016, to October 30, 2018. We included patients with jackhammer esophagus (JE; ≥2 swallows with distal contractile integral [DCI] ≥8,000 mm Hg∙cm∙s), nutcracker esophagus (NE; mean DCI 5,000-8,000 mm Hg∙cm∙s without meeting JE criteria), or esophagogastric junction outflow obstruction ([EGJOO]: abnormal median integrated relaxation pressure (>15 mm Hg) without meeting achalasia criteria, with JE [EGJOO-h], or normal motility [EGJOO-n]). HRM, endoscopy, barium esophagram, ambulatory pH studies, and symptom questionnaires were reevaluated for further analysis. Clinical parameters were analyzed using Spearman Rho correlation. Categorical variables were assessed with Fisher exact or chi-square test. RESULTS: Altogether, 85 patients met inclusion criteria. They were divided into 4 subgroups: 28 with JE, 18 with NE, 15 with EGJOO-h, and 24 with EGJOO-n. Patients with EGJOO-h were the most symptomatic overall. No correlation was seen between symptoms and mean DCI (p ≥ 0.05 all groups) or number of hypercontractile swallows (≥8,000 mm Hg∙cm∙s, p ≥ 0.05). A significant correlation was noted between dysphagia and lower esophageal sphincter pressure (LESP) and LESP integral (p ≤ 0.05). CONCLUSION: The number of hypercontractile swallows and mean DCI were not associated with patient-reported symptoms. Elevated LESP may be a more relevant contributor to dysphagia.
背景:高分辨率测压偶尔会发现食管高动力蠕动,但目前其临床相关性尚不清楚。本研究比较了食管高动力蠕动患者的症状严重程度和临床表现。
方法:这是一项回顾性队列研究。我们查询了 2016 年 10 月 1 日至 2018 年 10 月 30 日期间接受食管功能测试的患者的前瞻性维护数据库。我们纳入了存在痉挛性食管(≥2 次吞咽时远端收缩积分[DCI]≥8000mmHg·cm·s)、胡桃夹食管(NE;DCI 均值为 5000-8000mmHg·cm·s,但不符合痉挛性食管标准)或食管胃结合部流出道梗阻([EGJOO]:异常中位松弛压力(>15mmHg),但不符合贲门失弛缓症标准,伴有痉挛性食管[EGJOO-h]或正常动力[EGJOO-n])的患者。重新评估了 HRM、内镜、食管钡餐造影、动态 pH 研究和症状问卷以进行进一步分析。使用 Spearman Rho 相关性分析临床参数。使用 Fisher 精确检验或卡方检验评估分类变量。
结果:共有 85 例患者符合纳入标准。他们被分为 4 个亚组:28 例痉挛性食管,18 例 NE,15 例 EGJOO-h,24 例 EGJOO-n。总体而言,EGJOO-h 患者症状最明显。在所有组中,症状与平均 DCI(p≥0.05)或高动力蠕动吞咽次数(≥8000mmHg·cm·s,p≥0.05)之间均无相关性。吞咽困难与食管下括约肌压力(LESP)和 LESP 积分呈显著相关性(p≤0.05)。
结论:高动力蠕动吞咽次数和平均 DCI 与患者报告的症状无关。升高的 LESP 可能是导致吞咽困难的更相关因素。
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