Gimrikh E O, Gushchin I V, Chekhov A M, Popov S V, Mikhaĭlenko A I
Kardiologiia. 1988 Aug;28(8):47-51.
Combined effect of cordarone and ritmilen on myocardial electrophysiology was assessed in an acute medicated test, on the basis of electrophysiologic studies and transesophageal pacing test, in patients with resistant paroxysmal supraventricular tachycardia. The cordarone-ritmilen combination has proved efficient in 82.4% of cases and caused a significant change of the P-Q interval and effective refractory period (ERPav, ERPrv, ERPiv). The Q-T interval increased but never resulted in ventricular arrhythmias. Good antiarrhythmic effect was seen in 70.4% after 12 months. There were side effects in 10.7% of cases.
在一项急性药物试验中,基于电生理研究和经食管起搏试验,对患有顽固性阵发性室上性心动过速的患者评估了胺碘酮和丙吡胺对心肌电生理学的联合作用。胺碘酮 - 丙吡胺联合用药在82.4%的病例中证明有效,并使P - Q间期和有效不应期(ERPav、ERPrv、ERPiv)发生了显著变化。Q - T间期延长,但从未导致室性心律失常。12个月后,70.4%的患者有良好的抗心律失常效果。10.7%的病例出现了副作用。