X连锁遗传性肾炎综合征基因的定位
Localization of the gene for X-linked Alport's syndrome.
作者信息
Brunner H, Schröder C, van Bennekom C, Lambermon E, Tuerlings J, Menzel D, Olbing H, Monnens L, Wieringa B, Ropers H H
机构信息
Department of Human Genetics, University Hospital, Nijmegen, the Netherlands.
出版信息
Kidney Int. 1988 Oct;34(4):507-10. doi: 10.1038/ki.1988.210.
X-chromosomal DNA probes defining various polymorphic DNA markers were used to study genetic linkage in three families with Alport's syndrome. With the DXS17 marker, only a single cross-over was observed in 26 informative meioses, and evidence for linkage was also obtained with the DXS11 marker. These data localize the gene for the X-linked form of Alport's syndrome to the middle of the long arm of the X chromosome.
定义各种多态性DNA标记的X染色体DNA探针被用于研究三个患有阿尔波特综合征的家族中的遗传连锁情况。对于DXS17标记，在26次可提供信息的减数分裂中仅观察到一次交叉，并且使用DXS11标记也获得了连锁证据。这些数据将X连锁型阿尔波特综合征的基因定位到X染色体长臂的中部。
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