Choudhury Abrar, Neumann Neil M, Raleigh David R, Lang Ursula E
Department of Neurological Surgery, University of California, San Francisco, CA, USA.
Department of Radiation Oncology, University of California, San Francisco, CA, USA.
Dermatol Ther (Heidelb). 2020 Apr;10(2):233-248. doi: 10.1007/s13555-020-00355-1. Epub 2020 Jan 29.
The primary cilium is a cell surface organelle that is an important component of cellular biology. While it was once believed to be a vestigial structure without biologic function, it is now known to have essential roles in critical cellular signaling pathways such as Hedgehog (HH) and Wnt. The HH and Wnt pathways are involved in pathogenesis of basal cell carcinoma and melanoma, respectively, and this knowledge is now beginning to inform therapeutic and diagnostic options for patients. The purpose of this review is to familiarize clinicians with primary cilia biology and how this complex cellular organelle has started to translate into clinical care.
初级纤毛是一种细胞表面细胞器，是细胞生物学的重要组成部分。虽然它曾被认为是一种没有生物学功能的退化结构，但现在已知它在关键的细胞信号通路如刺猬信号通路（HH）和Wnt信号通路中发挥着重要作用。HH信号通路和Wnt信号通路分别参与基底细胞癌和黑色素瘤的发病机制，而这一认识目前已开始为患者的治疗和诊断选择提供依据。本综述的目的是让临床医生熟悉初级纤毛生物学，以及这种复杂的细胞器如何开始应用于临床护理。
