A Single-Cell Perspective of the Mammalian Liver in Health and Disease.

The liver contains heterogeneous cell types that exhibit distinct spatial, molecular, and functional properties. The cells in the liver communicate with each other via a network of ligands and receptors and undergo cell type-specific transcriptomic reprogramming in disease. The advance of single-cell genomics has provided a powerful tool for unraveling the complexity of liver cells in health and disease with unprecedented resolution. In this review, we discuss insights gained from the recent single-cell RNA sequencing studies that shed new light on the molecular nature of liver cell heterogeneity, intercellular crosstalk, and disease-associated reprogramming.