Faculty of Medicine, Istanbul University Cerrahpasa, Istanbul, Turkey.
Obstetrics and Gynecology, Division of Perinatology, Istanbul Universitesi Cerrahpasa Tip Fakultesi, Istanbul, Turkey.
Fetal Pediatr Pathol. 2021 Oct;40(5):493-500. doi: 10.1080/15513815.2019.1710790. Epub 2020 Jan 30.
Twin pregnancy with complete hydatidiform mole and co-existing fetus (CHMCF) is an uncommon obstetric entity and may occur after assisted reproductive technologies. These pregnancies are associated with severe complications for both mother and fetus and the management is challenging. We report a twin pregnancy after intracytoplasmic sperm injection (ICSI) treatment with CHMCF which delivered at 26 gestation weeks due to severe preeclampsia. The 625g neonate survived without any complication. The woman had persistent trophoblastic disease with lung metastasis and was treated with single agent methotrexate. We also present a brief review of the literature about the outcomes of CHMCF after ICSI. CHMCF may occur after ICSI treatment. Pregnancies with CHMCF are associated with severe complications however under close follow-up successful outcomes could be achieved in such pregnancies.
双胎妊娠合并完全性葡萄胎和共存胎儿（CHMCF）是一种罕见的产科疾病，可能发生在辅助生殖技术之后。这些妊娠对母亲和胎儿都有严重的并发症，治疗具有挑战性。我们报告了一例 ICSI 治疗后的双胎妊娠合并 CHMCF，由于严重的子痫前期，在 26 孕周分娩。625g 的新生儿存活，无任何并发症。该妇女患有持续性滋养细胞疾病伴肺转移，用单药甲氨蝶呤治疗。我们还对 ICSI 后 CHMCF 的文献进行了简要回顾。ICSI 治疗后可能发生 CHMCF。CHMCF 妊娠与严重并发症相关，但在密切随访下，此类妊娠可获得成功结局。
