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与抗谷氨酸脱羧酶抗体及僵人综合征相关的自身免疫性音乐源性癫痫

Autoimmune musicogenic epilepsy associated with anti-glutamic acid decarboxylase antibodies and Stiff-person syndrome.

作者信息

Jesus-Ribeiro Joana, Bozorgi Alireza, Alkhaldi Modhi, Shaqfeh Mahmoud, Fernandez-Baca Vaca Guadalupe, Katirji Bashar

机构信息

Neurology Department Coimbra University Hospital Center Coimbra Portugal.

Neurology Department University Hospitals Cleveland Medical Center and Case Western Reserve University School of Medicine Cleveland OH USA.

出版信息

Clin Case Rep. 2019 Dec 12;8(1):61-64. doi: 10.1002/ccr3.2538. eCollection 2020 Jan.

DOI:10.1002/ccr3.2538
PMID:31998487
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6982507/
Abstract

Epilepsy should be suspected in patients with Stiff-person syndrome and new onset paroxysmal episodes. Musicogenic epilepsy may be a manifestation of anti-GAD-Ab spectrum, supporting an autoimmune workup in these patients. Appropriate treatment is not well established, and immunotherapy should be considered in patients with only partial response to antiepileptic drugs.

摘要

僵人综合征患者出现新发阵发性发作时应怀疑癫痫。音乐性癫痫可能是抗谷氨酸脱羧酶抗体谱的一种表现,这支持对这些患者进行自身免疫性检查。目前尚无确定的合适治疗方法,对抗癫痫药物仅有部分反应的患者应考虑免疫治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72ef/6982507/c4af5b43c508/CCR3-8-61-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72ef/6982507/c4af5b43c508/CCR3-8-61-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/72ef/6982507/c4af5b43c508/CCR3-8-61-g001.jpg

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本文引用的文献

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Hippocampus and Insula Are Targets in Epileptic Patients With Glutamic Acid Decarboxylase Antibodies.海马体和脑岛是谷氨酸脱羧酶抗体阳性癫痫患者的靶点。
Front Neurol. 2019 Jan 9;9:1143. doi: 10.3389/fneur.2018.01143. eCollection 2018.
2
Correlation of vocals and lyrics with left temporal musicogenic epilepsy.
Ann N Y Acad Sci. 2018 Mar 15. doi: 10.1111/nyas.13594.
3
Antiglutamic acid decarboxylase 65 (GAD65) antibody-associated epilepsy.谷氨酸脱羧酶 65 抗体相关性癫痫。
颞叶癫痫中的音乐源性癫痫发作:基于发作源定位分析的病例报告
Front Neurol. 2023 Feb 20;14:1072075. doi: 10.3389/fneur.2023.1072075. eCollection 2023.
4
Seizure Semiology in Antibody-Associated Autoimmune Encephalitis.抗体相关性自身免疫性脑炎的发作症候学。
Neurol Neuroimmunol Neuroinflamm. 2022 Oct 20;9(6). doi: 10.1212/NXI.0000000000200034. Print 2022 Nov.
5
Musicogenic reflex seizure with positive antiglutamic decarboxylase antibody: A case report.谷氨酸脱羧酶抗体阳性的音乐性反射性癫痫发作:病例报告。
Epilepsia Open. 2021 Sep;6(3):607-610. doi: 10.1002/epi4.12518. Epub 2021 Jul 21.
6
GAD antibody-spectrum disorders: progress in clinical phenotypes, immunopathogenesis and therapeutic interventions.广泛性焦虑症抗体谱障碍:临床表型、免疫发病机制及治疗干预的进展
Ther Adv Neurol Disord. 2021 Mar 30;14:17562864211003486. doi: 10.1177/17562864211003486. eCollection 2021.
7
Clinical spectrum of high-titre GAD65 antibodies.高滴度GAD65抗体的临床谱
J Neurol Neurosurg Psychiatry. 2021 Feb 9;92(6):645-54. doi: 10.1136/jnnp-2020-325275.
Epilepsy Behav. 2018 Mar;80:331-336. doi: 10.1016/j.yebeh.2018.01.021. Epub 2018 Feb 9.
4
Musicogenic reflex seizures in epilepsy with glutamic acid decarbocylase antibodies.谷氨酸脱羧酶抗体相关性癫痫的音乐性反射性癫痫发作
Acta Neurol Scand. 2018 Feb;137(2):272-276. doi: 10.1111/ane.12799. Epub 2017 Aug 2.
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Tremor Other Hyperkinet Mov (N Y). 2016 Mar 4;6:340. doi: 10.7916/D85M65GD. eCollection 2016.
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Stiff person syndrome: advances in pathogenesis and therapeutic interventions.僵人综合征:发病机制和治疗干预的新进展。
Curr Treat Options Neurol. 2009 Mar;11(2):102-10. doi: 10.1007/s11940-009-0013-9.
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