CYP1A在内源代谢中的新见解：聚焦单核苷酸多态性与疾病
New insights of CYP1A in endogenous metabolism: a focus on single nucleotide polymorphisms and diseases.
作者信息
Lu Jian, Shang Xuyang, Zhong Weiguo, Xu Yuan, Shi Rong, Wang Xin
机构信息
Changning Maternity and Infant Health Hospital, East China Normal University, Shanghai 200051, China.
Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China.
出版信息
Acta Pharm Sin B. 2020 Jan;10(1):91-104. doi: 10.1016/j.apsb.2019.11.016. Epub 2019 Dec 2.
Cytochrome P450 1A (CYP1A), one of the major CYP subfamily in humans, not only metabolizes xenobiotics including clinical drugs and pollutants in the environment, but also mediates the biotransformation of important endogenous substances. In particular, some single nucleotide polymorphisms (SNPs) for genes may affect the metabolic ability of endogenous substances, leading to some physiological or pathological changes in humans. This review first summarizes the metabolism of endogenous substances by CYP1A, and then introduces the research progress of SNPs, especially the research related to human diseases. Finally, the relationship between SNPs and diseases is discussed. In addition, potential animal models for gene editing are summarized. In conclusion, CYP1A plays an important role in maintaining the health in the body.
细胞色素P450 1A（CYP1A）是人类主要的细胞色素P450亚家族之一，不仅能代谢包括临床药物和环境污染物在内的外源性物质，还介导重要内源性物质的生物转化。特别是，某些基因的单核苷酸多态性（SNP）可能会影响内源性物质的代谢能力，导致人类出现一些生理或病理变化。本文综述首先总结了CYP1A对内源性物质的代谢情况，然后介绍了SNP的研究进展，尤其是与人类疾病相关的研究。最后，讨论了SNP与疾病之间的关系。此外，还总结了基因编辑的潜在动物模型。总之，CYP1A在维持机体健康方面发挥着重要作用。
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