一种荧光萘酰亚胺 NADH 模拟物，用于连续和可逆地感测细胞氧化还原状态。
A fluorescent naphthalimide NADH mimic for continuous and reversible sensing of cellular redox state.
机构信息
School of Life and Environmental Sciences, Deakin University, Waurn Ponds, Victoria 3216, Australia.
School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia.
出版信息
Chem Commun (Camb). 2020 Feb 20;56(15):2240-2243. doi: 10.1039/c9cc09748a.
A fluorescent, naphthalimide-based, NADH mimic has been synthesised as a reversible, biocompatible, "on-off" probe for the detection of changes in intracellular redox environment (both oxidation and reduction). Interconversion was confirmed by means of electrochemistry and also 1H NMR, UV-vis and fluorescence spectroscopy. The reversibility was also successfully detected in A549 cells under simulated redox stress.
一种基于萘二甲酰亚胺的荧光 NADH 模拟物已被合成，作为一种可逆的、生物相容性的“开-关”探针，用于检测细胞内氧化还原环境的变化（氧化和还原）。通过电化学方法以及 1H NMR、UV-vis 和荧光光谱法证实了这种互变。在模拟氧化还原应激下，该化合物在 A549 细胞中的可逆性也得到了成功检测。
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