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一例罕见的肉瘤样肾细胞癌通过腹腔镜端口部位直接蔓延至皮肤。

An unusual case of sarcomatoid renal cell carcinoma presenting in the skin by direct extension at a laparoscopic port site.

作者信息

Gradecki Sarah E, Gru Alejandro A

机构信息

Department of Pathology, University of Virginia, Charlottesville, Virginia.

出版信息

J Cutan Pathol. 2020 Jul;47(7):617-620. doi: 10.1111/cup.13657. Epub 2020 Feb 18.

Abstract

Although renal cell carcinoma (RCC) is known for its propensity to metastasize widely throughout the body, cutaneous metastases are uncommon and seen in less than 3% of RCCs. A 56-year-old man presented with a painful red lesion with satellite nodules on his abdomen at a laparoscopic port site from a partial nephrectomy for a pT1a clear-cell RCC that was performed 28 months prior. The lesion was excised; however, after excision the lesion recurred with continued pain and drainage from the surgical site. This was treated with multiple courses of antibiotics. Because of the persistent nature of the lesion, it was re-biopsied, and an atypical, keratin-positive, spindle-cell proliferation was identified within the dermis. The patient's previous skin excision was reexamined, and the same atypical cells were identified within large areas of necrosis, granulation tissue, and fibrosis. Further workup was performed on the initial excision, and the atypical cells showed expression of CD10, CAIX, PAX8, EMA, and vimentin, consistent with cutaneous involvement by RCC. Because of the rarity of skin metastases in RCC and the location at a previous laparoscopic port site, this lesion is presumed to have resulted from direct extension of tumor at the time of surgery.

摘要

尽管肾细胞癌(RCC)以易于在全身广泛转移而闻名,但皮肤转移并不常见,在不到3%的RCC病例中可见。一名56岁男性,在28个月前因pT1a期透明细胞肾细胞癌接受了部分肾切除术,其腹部腹腔镜切口部位出现一个疼痛的红色病灶,并伴有卫星结节。该病灶被切除;然而,切除后病灶复发,手术部位持续疼痛并有渗液。对此进行了多疗程抗生素治疗。由于病灶持续存在,再次进行活检,在真皮内发现了非典型的、角蛋白阳性的梭形细胞增殖。对患者之前的皮肤切除标本重新检查,在大片坏死、肉芽组织和纤维化区域内发现了相同的非典型细胞。对最初切除的标本进行了进一步检查,非典型细胞显示CD10、CAIX、PAX8、EMA和波形蛋白表达阳性,符合肾细胞癌皮肤转移。由于肾细胞癌皮肤转移罕见,且发生在先前腹腔镜切口部位,推测该病灶是手术时肿瘤直接蔓延所致。

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