Da Rocha Jaqueline Abel, Da Silva Natalia Chilinque Zambão, Silva Ana Sdn, Garrido Rafael Guaresma, Moreira Beatriz Meurer, Martins Ianick Souto
Universidade Federal Fluminense, Niterói, RJ, Brazil.
Instituto Nacional de Cardiologia, Rio de Janeiro, Brazil.
J Infect Dev Ctries. 2018 Sep 30;12(9):806-807. doi: 10.3855/jidc.10587.
Non-diphtheriae Corynebacterium species are usually considered as contaminants of clinical specimens due to their widely environmental distribution and colonization of the human skin and mucous membranes. However, these bacteria have been increasingly recognized as agents of life-threatening infections mainly in individuals in immunosuppressive conditions. These organisms have vast variation in morphology and biochemical reaction, characteristics that make the correct identification of Corynebacterium at the species level extremely difficult using conventional phenotypic methods. The precise identification of C. amycolatum requires approaches rarely available in conventional clinical microbiology laboratories, such as API Coryne system, 16s rRNA and rpoB gene sequencing. In this setting, MALDI-TOF, a quick, accurate, and relatively unexpansive molecular technique, arises as a cost-effective alternative for characterizing these agents. Here, a rare and lethal case of endocarditis caused by C. amycolatum is presented. This is the first case of infective endocarditis due to C. amycolatum reported in Brazil.
非白喉棒状杆菌属通常被视为临床标本的污染物，因为它们广泛分布于环境中，并在人体皮肤和黏膜定殖。然而，这些细菌越来越多地被认为是主要在免疫抑制个体中引起危及生命感染的病原体。这些微生物在形态和生化反应方面有很大差异，这些特性使得使用传统表型方法在种水平上正确鉴定棒状杆菌极其困难。精确鉴定无糖棒状杆菌需要传统临床微生物实验室很少采用的方法，如API Coryne系统、16s rRNA和rpoB基因测序。在这种情况下，基质辅助激光解吸电离飞行时间质谱（MALDI-TOF）作为一种快速、准确且相对经济的分子技术，成为表征这些病原体的一种经济有效的替代方法。在此，报告一例由无糖棒状杆菌引起的罕见致命性心内膜炎病例。这是巴西报道的首例由无糖棒状杆菌引起的感染性心内膜炎病例。
