GSTM1 和 GSTT1 基因型在分化型甲状腺癌中的作用及其与生活方式因素的相互作用：来自法国和新喀里多尼亚病例对照研究的结果。
Role of GSTM1 and GSTT1 genotypes in differentiated thyroid cancer and interaction with lifestyle factors: Results from case-control studies in France and New Caledonia.
机构信息
Université Paris-Saclay, UVSQ, INSERM, CESP, Villejuif, France.
Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, USPC, Université Paris Descartes, Université Paris Diderot, EPIGENETEC, Paris, France.
出版信息
PLoS One. 2020 Jan 30;15(1):e0228187. doi: 10.1371/journal.pone.0228187. eCollection 2020.
BACKGROUND
GSTM1 and GSTT1 are involved in detoxification of xenobiotics, products of oxidative stress and in steroid hormones metabolism. We investigated whether GSTM1 and GSTT1 gene deletion was associated with DTC risk and explored interaction with non-genetic risk factors of DTC.
METHODS
The study included 661 DTC cases and 736 controls from two case-control studies conducted in France and New Caledonia. Odds ratios (OR) and their confidence interval (CI) for DTC associated with GST genotypes, alcohol drinking, tobacco smoking, body mass index and hormonal factors were calculated using logistic regression models.
RESULTS
Results are presented for Europeans and Melanesians combined, as no heterogeneity between groups was detected. We found that DTC risk increased with obesity and decrease with alcohol drinking. After stratification by gene deletion status, the OR for obesity was 5.75, (95%CI 2.25-14.7) among individuals with GSTT1 and GSTM1-deleted genotype, and 1.26, (95%CI 0.89-1.77) in carriers of both genes (p-interaction = 0.02). The OR for drinking ≥1 glass/week was 0.33 (95%CI 0.15-0.74) in GSTT1-null individuals while it was 1.01 (95%CI 0.67-1.52) in non-null carriers of the gene (p-interaction = 0.01). No interaction between GST genotypes and other non-genetic risk factors was detected.
CONCLUSION
GSTM1 and GSTT1 genotypes may modulate the DTC risk associated with BMI and alcohol consumption.
背景
GSTM1 和 GSTT1 参与外源性化学物质、氧化应激产物和甾体激素代谢的解毒。我们研究了 GSTM1 和 GSTT1 基因缺失是否与 DTC 风险相关，并探讨了与 DTC 非遗传危险因素的相互作用。
方法
这项研究包括来自法国和新喀里多尼亚两项病例对照研究的 661 例 DTC 病例和 736 例对照。使用逻辑回归模型计算 GST 基因型、饮酒、吸烟、体重指数和激素因素与 DTC 相关的比值比（OR）及其置信区间（CI）。
结果
结果综合了欧洲人和美拉尼西亚人，因为两组之间没有发现异质性。我们发现 DTC 风险随着肥胖而增加，随着饮酒而减少。根据基因缺失状态分层后，在 GSTT1 和 GSTM1 缺失基因型个体中，肥胖的 OR 为 5.75（95%CI 2.25-14.7），而在两个基因携带者中为 1.26（95%CI 0.89-1.77）（p 交互作用=0.02）。每周饮酒≥1 杯的 OR 在 GSTT1 缺失个体中为 0.33（95%CI 0.15-0.74），而在基因非缺失携带者中为 1.01（95%CI 0.67-1.52）（p 交互作用=0.01）。未发现 GST 基因型与其他非遗传危险因素之间存在相互作用。
结论
GSTM1 和 GSTT1 基因型可能调节 BMI 和饮酒与 DTC 风险之间的关联。
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