Ramprasath Tharmarajan, Freddy Allen John, Velmurugan Ganesan, Tomar Dhanendra, Rekha Balakrishnan, Suvekbala Vemparthan, Ramasamy Subbiah
Department of Molecular Biology, School of Biological Sciences, Madurai Kamaraj University, Madurai 625021, Tamil Nadu, India.
Department of Zoology, Madras Christian College, Chennai 600 059, Tamil Nadu, India.
Curr Diabetes Rev. 2020;16(8):797-806. doi: 10.2174/1573399816666200130094512.
Diabetes mellitus is associated with an increased risk of micro and macrovascular complications. During hyperglycemic conditions, endothelial cells and vascular smooth muscle cells are exquisitely sensitive to high glucose. This high glucose-induced sustained reactive oxygen species production leads to redox imbalance, which is associated with endothelial dysfunction and vascular wall remodeling. Nrf2, a redox-regulated transcription factor plays a key role in the antioxidant response element (ARE)-mediated expression of antioxidant genes. Although accumulating data indicate the molecular mechanisms underpinning the Nrf2 regulated redox balance, understanding the influence of the Nrf2/ARE axis during hyperglycemic condition on vascular cells is paramount. This review focuses on the context-dependent role of Nrf2/ARE signaling on vascular endothelial and smooth muscle cell function during hyperglycemic conditions. This review also highlights improving the Nrf2 system in vascular tissues, which could be a potential therapeutic strategy for vascular dysfunction.
糖尿病与微血管和大血管并发症风险增加相关。在高血糖状态下，内皮细胞和血管平滑肌细胞对高糖极为敏感。这种由高糖诱导的持续活性氧生成会导致氧化还原失衡，而氧化还原失衡与内皮功能障碍和血管壁重塑有关。Nrf2是一种氧化还原调节转录因子，在抗氧化反应元件（ARE）介导的抗氧化基因表达中起关键作用。尽管越来越多的数据表明了支撑Nrf2调节氧化还原平衡的分子机制，但了解高血糖状态下Nrf2/ARE轴对血管细胞的影响至关重要。本综述重点关注高血糖状态下Nrf2/ARE信号对血管内皮和平滑肌细胞功能的背景依赖性作用。本综述还强调改善血管组织中的Nrf2系统，这可能是治疗血管功能障碍的一种潜在策略。
