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Phase I Study of Selinexor, Ixazomib, and Low-dose Dexamethasone in Patients With Relapsed or Refractory Multiple Myeloma.塞利尼索、伊沙佐米和低剂量地塞米松用于复发或难治性多发性骨髓瘤患者的I期研究。
Clin Lymphoma Myeloma Leuk. 2020 Mar;20(3):198-200. doi: 10.1016/j.clml.2019.12.013. Epub 2019 Dec 26.
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Survival benefit of ixazomib, lenalidomide and dexamethasone (IRD) over lenalidomide and dexamethasone (Rd) in relapsed and refractory multiple myeloma patients in routine clinical practice.在常规临床实践中，来那度胺和地塞米松（Rd）与伊沙佐米、来那度胺和地塞米松（IRD）相比，对复发和难治性多发性骨髓瘤患者的生存获益。
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Lowering the Selinexor Dose within the Pomalidomide and Dexamethasone Combination Regimen Elicits Fewer Side Effects While Comparable Efficacy Against Relapsed/Refractory Multiple Myeloma.在泊马度胺和地塞米松联合方案中降低塞利尼索剂量可减少副作用，同时对复发/难治性多发性骨髓瘤具有相当的疗效。
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Ther Adv Hematol. 2024 Jan 5;15:20406207231219442. doi: 10.1177/20406207231219442. eCollection 2024.
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EJHaem. 2023 May 15;4(3):792-810. doi: 10.1002/jha2.709. eCollection 2023 Aug.
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The Role of Belantamab Mafodotin, Selinexor, and Melflufen in Multiple Myeloma.贝兰他单抗马妥昔单抗、塞利尼索和来那度胺在多发性骨髓瘤中的作用。
Curr Hematol Malig Rep. 2022 Dec;17(6):306-318. doi: 10.1007/s11899-022-00682-4. Epub 2022 Nov 22.
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Efficacy and safety of selinexor-based regimens for relapsed/refractory multiple myeloma: a systematic review of literature.基于塞利尼索的方案治疗复发/难治性多发性骨髓瘤的疗效和安全性：文献系统评价
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Ixazomib with cyclophosphamide and dexamethasone in relapsed or refractory myeloma: MUKeight phase II randomised controlled trial results.来那度胺联合环磷酰胺和地塞米松治疗复发或难治性多发性骨髓瘤：MUKeight 期随机对照试验结果。
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Novel Approaches Outside the Setting of Immunotherapy for the Treatment of Multiple Myeloma: The Case of Melflufen, Venetoclax, and Selinexor.多发性骨髓瘤治疗中免疫治疗之外的新型方法：美法仑氟芬、维奈克拉和塞利尼索的案例
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Clinical Utility of Selinexor/Dexamethasone in Patients with Relapsed or Refractory Multiple Myeloma: A Review of Current Evidence and Patient Selection.塞利尼索/地塞米松在复发或难治性多发性骨髓瘤患者中的临床应用：当前证据及患者选择综述
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本文引用的文献

1
Phase 1 study of selinexor plus carfilzomib and dexamethasone for the treatment of relapsed/refractory multiple myeloma.Selinexor 联合卡非佐米和地塞米松治疗复发/难治性多发性骨髓瘤的 1 期研究。
Br J Haematol. 2019 Aug;186(4):549-560. doi: 10.1111/bjh.15969. Epub 2019 May 24.
2
Selinexor plus low-dose bortezomib and dexamethasone for patients with relapsed or refractory multiple myeloma.塞利尼索联合低剂量硼替佐米和地塞米松治疗复发/难治性多发性骨髓瘤患者。
Blood. 2018 Dec 13;132(24):2546-2554. doi: 10.1182/blood-2018-06-858852. Epub 2018 Oct 23.
3
Selective Inhibition of Nuclear Export With Oral Selinexor for Treatment of Relapsed or Refractory Multiple Myeloma.口服 Selinexor 选择性抑制核输出治疗复发/难治性多发性骨髓瘤。
J Clin Oncol. 2018 Mar 20;36(9):859-866. doi: 10.1200/JCO.2017.75.5207. Epub 2018 Jan 30.

Phase I Study of Selinexor, Ixazomib, and Low-dose Dexamethasone in Patients With Relapsed or Refractory Multiple Myeloma.

作者信息

Salcedo Meghan, Lendvai Nikoletta, Mastey Donna, Schlossman Julia, Hultcrantz Malin, Korde Neha, Mailankody Sham, Lesokhin Alexander, Hassoun Hani, Smith Eric, Shah Urvi, Diab Victoria, Werner Kelly, Landau Heather, Lahoud Oscar, Drullinsky Pamela, Shah Gunjan, Chung David, Scordo Michael, Giralt Sergio, Landgren Ola

机构信息

Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.

Adult Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.

出版信息

Clin Lymphoma Myeloma Leuk. 2020 Mar;20(3):198-200. doi: 10.1016/j.clml.2019.12.013. Epub 2019 Dec 26.

DOI:10.1016/j.clml.2019.12.013
PMID:32001193
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7405911/
Abstract
摘要