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天然产物针对慢性病的特征靶标。

Natural products target the hallmarks of chronic diseases.

机构信息

Department of Pharmacy, College of Pharmacy, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea.

出版信息

Biochem Pharmacol. 2020 Mar;173:113828. doi: 10.1016/j.bcp.2020.113828. Epub 2020 Jan 28.

Abstract

Natural compounds are known to display therapeutic potential against a variety of chronic conditions, including cancer and inflammation. The efficacy of these natural substances can be associated with numerous molecular scaffolds present in extracts of living organisms, both terrestrial and marine. Recently, investigators have identified the ability of natural compounds to trigger immunogenic cell death and subsequent activation of the adaptive immune system. Such findings indicate that the full therapeutic potential of natural products has yet to be defined, and further investigations on such agents will continue to yield novel drug candidates.

摘要

天然化合物被认为对多种慢性疾病具有治疗潜力,包括癌症和炎症。这些天然物质的疗效可能与陆地和海洋生物提取物中存在的许多分子支架有关。最近,研究人员已经确定了天然化合物触发免疫原性细胞死亡和随后激活适应性免疫系统的能力。这些发现表明,天然产物的全部治疗潜力尚未得到明确界定,对这些药物的进一步研究将继续产生新的候选药物。

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