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通过对骨骼遗骸进行27个大陆祖先信息单核苷酸多态性分析来解决一起法医案件。

Twenty-seven continental ancestry-informative SNP analysis of bone remains to resolve a forensic case.

作者信息

Sun Qifan, Jiang Li, Zhang Guangfeng, Liu Jing, Zhao Lei, Zhao Wenting, Li Caixia

机构信息

Key Laboratory of Forensic Genetics, Beijing Engineering Research Center of Crime Scene Evidence Examination, Institute of Forensic Science, Ministry of Public Security, Beijing, China.

出版信息

Forensic Sci Res. 2017 May 19;4(4):364-366. doi: 10.1080/20961790.2017.1306431. eCollection 2019.

Abstract

We employed our previously developed 27-plex ancestry-informative single nucleotide polymorphism (SNP) panel to infer the ancestral components of bone remains of a possible foreign pilot found in south-western China. For ancestry assignment of this unknown individual, we first obtained the 27-SNP genotype of the individual. Then, based on a reference database of 3081 individuals from 33 populations, we calculated the match probability and likelihood ratio using the self-developed software program Forensic Intelligence. Inferred ancestral components of this individual were calculated by structure at = 3. A complete profile was obtained for the individual using our multiplexed SNP assay. The European population was within one order of magnitude of the highest likelihood. The major ancestral component of this individual was 97.6% European.

摘要

我们使用之前开发的包含27个单核苷酸多态性(SNP)的祖先信息面板,来推断在中国西南部发现的一具可能是外国飞行员的骨骼遗骸的祖先成分。为了对这个身份不明的个体进行祖先归属分析,我们首先获取了该个体的27个SNP基因型。然后,基于来自33个群体的3081个个体的参考数据库,我们使用自行开发的软件程序“法医智能”计算了匹配概率和似然比。通过Structure软件在K = 3时计算出该个体的推断祖先成分。使用我们的多重SNP检测方法为该个体获得了完整的图谱。欧洲人群的似然性处于最高似然性的一个数量级范围内。该个体的主要祖先成分是97.6%的欧洲人。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0848/6968571/563cd0d04046/TFSR_A_1306431_F0001_OC.jpg

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