Immunoglobulin heavy variable somatic hyper mutation status in chronic lymphocytic leukaemia: on the threshold of a new era?
作者信息
Langerak Anton W, Davi Frédéric, Stamatopoulos Kostas
机构信息
Laboratory Medical Immunology, Department of Immunology, Erasmus MC, Rotterdam, The Netherlands.
Hôpital Pitié-Salpêtrière, Sorbonne University, Paris, France.
出版信息
Br J Haematol. 2020 Jun;189(5):809-810. doi: 10.1111/bjh.16480. Epub 2020 Jan 30.
Abstract
摘要
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Immunoglobulin heavy chain variable region gene and prediction of time to first treatment in patients with chronic lymphocytic leukemia: Mutational load or mutational status? Analysis of 1003 cases.免疫球蛋白重链可变区基因与慢性淋巴细胞白血病患者首次治疗时间的预测：突变负荷还是突变状态？1003例病例分析。
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The absolute percent deviation of IGHV mutation rather than a 98% cut-off predicts survival of chronic lymphocytic leukaemia patients treated with fludarabine, cyclophosphamide and rituximab.免疫球蛋白重链可变区（IGHV）突变的绝对百分比偏差而非98%的临界值可预测接受氟达拉滨、环磷酰胺和利妥昔单抗治疗的慢性淋巴细胞白血病患者的生存率。
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